Seroatlas · Human Serome Atlas

TRAM1

Translocating chain-associated membrane protein 1

Also known as: TRAM, TRAM1_HUMAN, TRAMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15629
Gene
TRAM1
Ensembl
ENSG00000067167
Chromosome
8
Canonical length
374 aa
Protein class
Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q15629|TRAM1
     1  MAIRKKSTKS PPVLSHEFVL QNHADIVSCV AMVFLLGLMF EITAKASIIF VTLQYNVTLP
    61  ATEEQATESV SLYYYGIKDL ATVFFYMLVA IIIHAVIQEY MLDKINRRMH FSKTKHSKFN
   121  ESGQLSAFYL FACVWGTFIL ISENYISDPT ILWRAYPHNL MTFQMKFFYI SQLAYWLHAF
   181  PELYFQKTKK EDIPRQLVYI GLYLFHIAGA YLLNLNHLGL VLLVLHYFVE FLFHISRLFY
   241  FSNEKYQKGF SLWAVLFVLG RLLTLILSVL TVGFGLARAE NQKLDFSTGN FNVLAVRIAV
   301  LASICVTQAF MMWKFINFQL RRWREHSAFQ APAVKKKPTV TKGRSSKKGT ENGVNGTLTS
   361  NVADSPRNKK EKSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
183 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 183 nTPM
  • liver: 178 nTPM
  • pancreas: 166 nTPM
  • thyroid gland: 160 nTPM
  • epididymis: 140 nTPM
  • lung: 138 nTPM

Single-cell type

  • alveolar cells type 1: 1,042 nCPM
  • plasma cells: 628 nCPM
  • transitional alveolar cells: 444 nCPM
  • alveolar cells type 2: 439 nCPM
  • late spermatids: 386 nCPM
  • esophageal apical cells: 353 nCPM

Immune cell

  • total PBMC: 232 nTPM
  • plasmacytoid DC: 191 nTPM
  • MAIT T-cell: 154 nTPM
  • basophil: 151 nTPM
  • T-reg: 147 nTPM
  • memory CD8 T-cell: 138 nTPM

Brain region

  • choroid plexus: 78 nTPM
  • white matter: 48 nTPM
  • medulla oblongata: 46 nTPM
  • hypothalamus: 43 nTPM
  • thalamus: 39 nTPM
  • spinal cord: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.93
gnomAD missense Z
1.54
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAM1 as an antibody target. Whether an autoantibody or antibody against TRAM1 could matter depends on whether native TRAM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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