SEC62
Translocation protein SEC62
Also known as: Dtrp1, HTP1, SEC62_HUMAN, TLOC1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99442
- Gene
- SEC62
- Ensembl
- ENSG00000008952
- Chromosome
- 3
- Canonical length
- 399 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Endoplasmic reticulum,Intermediate filaments
OverviewNCBI Gene
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
399 residues, UniProt reviewed canonical sequence.
>Q99442|SEC62
1 MAERRRHKKR IQEVGEPSKE EKAVAKYLRF NCPTKSTNMM GHRVDYFIAS KAVDCLLDSK
61 WAKAKKGEEA LFTTRESVVD YCNRLLKKQF FHRALKVMKM KYDKDIKKEK DKGKAESGKE
121 EDKKSKKENI KDEKTKKEKE KKKDGEKEES KKEETPGTPK KKETKKKFKL EPHDDQVFLD
181 GNEVYVWIYD PVHFKTFVMG LILVIAVIAA TLFPLWPAEM RVGVYYLSVG AGCFVASILL
241 LAVARCILFL IIWLITGGRH HFWFLPNLTA DVGFIDSFRP LYTHEYKGPK ADLKKDEKSE
301 TKKQQKSDSE EKSDSEKKED EEGKVGPGNH GTEGSGGERH SDTDSDRRED DRSQHSSGNG
361 NDFEMITKEE LEQQTDGDCE EDEEEENDGE TPKSSHEKSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SEC62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 181 nTPM
Expression across tissuesHPA
Tissue
- liver: 181 nTPM
- epididymis: 125 nTPM
- salivary gland: 123 nTPM
- retina: 119 nTPM
- thyroid gland: 113 nTPM
- kidney: 111 nTPM
Single-cell type
- hepatocytes: 1,165 nCPM
- gastric chief cells: 992 nCPM
- epididymal principal cells: 970 nCPM
- parietal cells: 833 nCPM
- plasma cells: 682 nCPM
- epididymal efferent duct absorptive cells: 673 nCPM
Immune cell
- naive B-cell: 82 nTPM
- memory B-cell: 78 nTPM
- eosinophil: 62 nTPM
- neutrophil: 52 nTPM
- naive CD4 T-cell: 51 nTPM
- MAIT T-cell: 49 nTPM
Brain region
- hypothalamus: 159 nTPM
- midbrain: 141 nTPM
- white matter: 139 nTPM
- medulla oblongata: 139 nTPM
- spinal cord: 137 nTPM
- cerebral cortex: 132 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.3
- gnomAD pLI
- 0.98
- gnomAD missense Z
- 1.78
- DepMap mean gene effect
- -0.38
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cotranslational protein targeting to membrane
- post-translational protein targeting to endoplasmic reticulum membrane
- post-translational protein targeting to membrane, translocation
- reticulophagy
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Translocation protein Sec62
- Translocation protein Sec62
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SEC62 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SEC62 as an antibody target. Whether an autoantibody or antibody against SEC62 could matter depends on whether native SEC62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SEC62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SEC62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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