Seroatlas · Human Serome Atlas

SERP1

Stress-associated endoplasmic reticulum protein 1

Also known as: FLJ43424, RAMP4, SERP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6X1
Gene: SERP1
Ensembl: ENSG00000120742
Chromosome: 3
Canonical length: 66 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to act upstream of or within several processes, including positive regulation of organ growth; positive regulation of peptide hormone secretion; and positive regulation of translation. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

66 residues, UniProt reviewed canonical sequence.

>Q9Y6X1|SERP1
     1  MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APEEKASVGP WLLALFIFVV CGSAIFQIIQ
    61  SIRMGM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 235 nTPM

Expression across tissuesHPA

Tissue

pancreas: 235 nTPM
salivary gland: 175 nTPM
epididymis: 149 nTPM
liver: 148 nTPM
stomach: 108 nTPM
thyroid gland: 106 nTPM

Single-cell type

esophageal apical cells: 1,646 nCPM
syncytiotrophoblasts: 1,233 nCPM
epididymal principal cells: 1,125 nCPM
plasma cells: 910 nCPM
gastric chief cells: 866 nCPM
late spermatids: 845 nCPM

Immune cell

total PBMC: 509 nTPM
non-classical monocyte: 459 nTPM
classical monocyte: 412 nTPM
intermediate monocyte: 400 nTPM
eosinophil: 376 nTPM
basophil: 349 nTPM

Brain region

white matter: 69 nTPM
cerebral cortex: 68 nTPM
hypothalamus: 64 nTPM
thalamus: 64 nTPM
spinal cord: 64 nTPM
basal ganglia: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.27
gnomAD missense Z: 0.9
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERP1 as an antibody target. Whether an autoantibody or antibody against SERP1 could matter depends on whether native SERP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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