Seroatlas · Human Serome Atlas

PGRMC1

Membrane-associated progesterone receptor component 1

Also known as: HPR6.6, PGRC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00264
Gene
PGRMC1
Ensembl
ENSG00000101856
Chromosome
X
Canonical length
195 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Mid piece,Principal piece
Secretome location
Secreted - unknown location
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>O00264|PGRMC1
     1  MAAEDVVATG ADPSDLESGG LLHEIFTSPL NLLLLGLCIF LLYKIVRGDQ PAASGDSDDD
    61  EPPPLPRLKR RDFTPAELRR FDGVQDPRIL MAINGKVFDV TKGRKFYGPE GPYGVFAGRD
   121  ASRGLATFCL DKEALKDEYD DLSDLTAAQQ ETLSDWESQF TFKYHHVGKL LKEGEEPTVY
   181  SDEEEPKDES ARKND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGRMC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
633 nTPM

Expression across tissuesHPA

Tissue

  • liver: 633 nTPM
  • epididymis: 258 nTPM
  • kidney: 220 nTPM
  • seminal vesicle: 189 nTPM
  • spinal cord: 176 nTPM
  • hypothalamus: 173 nTPM

Single-cell type

  • platelets: 1,900 nCPM
  • hepatocytes: 523 nCPM
  • enterocytes: 353 nCPM
  • smooth muscle cells: 286 nCPM
  • epididymal efferent duct absorptive cells: 280 nCPM
  • other brain neurons: 218 nCPM

Immune cell

  • total PBMC: 50 nTPM
  • basophil: 21 nTPM
  • eosinophil: 20 nTPM
  • classical monocyte: 20 nTPM
  • intermediate monocyte: 20 nTPM
  • non-classical monocyte: 19 nTPM

Brain region

  • hypothalamus: 181 nTPM
  • pons: 180 nTPM
  • white matter: 158 nTPM
  • midbrain: 143 nTPM
  • spinal cord: 135 nTPM
  • cerebral cortex: 129 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PGRMC1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0.67
gnomAD missense Z
0.08
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PGRMC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGRMC1 as an antibody target. Whether an autoantibody or antibody against PGRMC1 could matter depends on whether native PGRMC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGRMC1 is annotated as secreted, so native PGRMC1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PGRMC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PGRMC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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