Seroatlas · Human Serome Atlas

ACBD3

Golgi resident protein GCP60

Also known as: GCP60, GCP60_HUMAN, GOCAP1, GOLPH1, PAP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3P7
Gene: ACBD3
Ensembl: ENSG00000182827
Chromosome: 1
Canonical length: 528 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>Q9H3P7|ACBD3
     1  MAAVLNAERL EVSVDGLTLS PDPEERPGAE GAPLLPPPLP PPSPPGSGRG PGASGEQPEP
    61  GEAAAGGAAE EARRLEQRWG FGLEELYGLA LRFFKEKDGK AFHPTYEEKL KLVALHKQVL
   121  MGPYNPDTCP EVGFFDVLGN DRRREWAALG NMSKEDAMVE FVKLLNRCCH LFSTYVASHK
   181  IEKEEQEKKR KEEEERRRRE EEERERLQKE EEKRRREEEE RLRREEEERR RIEEERLRLE
   241  QQKQQIMAAL NSQTAVQFQQ YAAQQYPGNY EQQQILIRQL QEQHYQQYMQ QLYQVQLAQQ
   301  QAALQKQQEV VVAGSSLPTS SKVNATVPSN MMSVNGQAKT HTDSSEKELE PEAAEEALEN
   361  GPKESLPVIA APSMWTRPQI KDFKEKIQQD ADSVITVGRG EVVTVRVPTH EEGSYLFWEF
   421  ATDNYDIGFG VYFEWTDSPN TAVSVHVSES SDDDEEEEEN IGCEEKAKKN ANKPLLDEIV
   481  PVYRRDCHEE VYAGSHQYPG RGVYLLKFDN SYSLWRSKSV YYRVYYTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACBD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

stomach: 30 nTPM
placenta: 30 nTPM
esophagus: 29 nTPM
thyroid gland: 27 nTPM
parathyroid gland: 26 nTPM
cervix: 26 nTPM

Single-cell type

cone photoreceptor cells: 292 nCPM
esophageal apical cells: 230 nCPM
plasma cells: 211 nCPM
epididymal principal cells: 186 nCPM
extravillous trophoblasts: 181 nCPM
mast cells: 172 nCPM

Immune cell

memory B-cell: 5 nTPM
naive B-cell: 4.4 nTPM
basophil: 2.1 nTPM
intermediate monocyte: 1.8 nTPM
T-reg: 1.7 nTPM
MAIT T-cell: 1.6 nTPM

Brain region

choroid plexus: 34 nTPM
midbrain: 29 nTPM
hypothalamus: 29 nTPM
thalamus: 27 nTPM
spinal cord: 27 nTPM
cerebellum: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACBD3.

Disease | ImmuneIEDB

Conditions an epitope on ACBD3 was assayed in.

pancreatic ductal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.01
gnomAD missense Z: 1.82
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

steroid biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACBD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACBD3 as an antibody target. Whether an autoantibody or antibody against ACBD3 could matter depends on whether native ACBD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACBD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACBD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...