PGRMC2
Membrane-associated progesterone receptor component 2
Also known as: DG6, PGRC2_HUMAN, PMBP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O15173
- Gene
- PGRMC2
- Ensembl
- ENSG00000164040
- Chromosome
- 4
- Canonical length
- 223 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Nuclear bodies,Plasma membrane,Cytosol
- Secretome location
- Secreted - unknown location
OverviewNCBI Gene
Enables heme binding activity. Involved in adipose tissue development. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
223 residues, UniProt reviewed canonical sequence.
>O15173|PGRMC2
1 MAAGDGDVKL GTLGSGSESS NDGGSESPGD AGAAAEGGGW AAAALALLTG GGEMLLNVAL
61 VALVLLGAYR LWVRWGRRGL GAGAGAGEES PATSLPRMKK RDFSLEQLRQ YDGSRNPRIL
121 LAVNGKVFDV TKGSKFYGPA GPYGIFAGRD ASRGLATFCL DKDALRDEYD DLSDLNAVQM
181 ESVREWEMQF KEKYDYVGRL LKPGEEPSEY TDEEDTKDHN KQDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PGRMC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 162 nTPM
Expression across tissuesHPA
Tissue
- liver: 162 nTPM
- duodenum: 120 nTPM
- small intestine: 115 nTPM
- adipose tissue: 101 nTPM
- skin: 93 nTPM
- stomach: 90 nTPM
Single-cell type
- syncytiotrophoblasts: 371 nCPM
- corticotrophs: 219 nCPM
- extravillous trophoblasts: 199 nCPM
- enterocytes: 169 nCPM
- esophageal apical cells: 155 nCPM
- parietal cells: 141 nCPM
Immune cell
- plasmacytoid DC: 2.4 nTPM
- basophil: 2.2 nTPM
- eosinophil: 2 nTPM
- T-reg: 2 nTPM
- memory CD4 T-cell: 1.8 nTPM
- naive CD4 T-cell: 1.6 nTPM
Brain region
- choroid plexus: 57 nTPM
- hypothalamus: 49 nTPM
- midbrain: 47 nTPM
- white matter: 46 nTPM
- pons: 43 nTPM
- cerebral cortex: 42 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.59
- gnomAD pLI
- 0.68
- gnomAD missense Z
- 0.84
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PGRMC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PGRMC2 as an antibody target. Whether an autoantibody or antibody against PGRMC2 could matter depends on whether native PGRMC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PGRMC2 is annotated as secreted, so native PGRMC2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PGRMC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...