Seroatlas · Human Serome Atlas

PREB

Guanine nucleotide-exchange factor SEC12

Also known as: SEC12, SEC12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCU5
Gene
PREB
Ensembl
ENSG00000138073
Chromosome
2
Canonical length
417 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

417 residues, UniProt reviewed canonical sequence.

>Q9HCU5|PREB
     1  MGRRRAPELY RAPFPLYALQ VDPSTGLLIA AGGGGAAKTG IKNGVHFLQL ELINGRLSAS
    61  LLHSHDTETR ATMNLALAGD ILAAGQDAHC QLLRFQAHQQ QGNKAEKAGS KEQGPRQRKG
   121  AAPAEKKCGA ETQHEGLELR VENLQAVQTD FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV
   181  WKVPSLEKVL EFKAHEGEIE DLALGPDGKL VTVGRDLKAS VWQKDQLVTQ LHWQENGPTF
   241  SSTPYRYQAC RFGQVPDQPA GLRLFTVQIP HKRLRQPPPC YLTAWDGSNF LPLRTKSCGH
   301  EVVSCLDVSE SGTFLGLGTV TGSVAIYIAF SLQCLYYVRE AHGIVVTDVA FLPEKGRGPE
   361  LLGSHETALF SVAVDSRCQL HLLPSRRSVP VWLLLLLCVG LIIVTILLLQ SAFPGFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PREB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
135 nTPM

Expression across tissuesHPA

Tissue

  • liver: 135 nTPM
  • skeletal muscle: 131 nTPM
  • tongue: 105 nTPM
  • epididymis: 100 nTPM
  • pancreas: 73 nTPM
  • heart muscle: 60 nTPM

Single-cell type

  • epididymal principal cells: 127 nCPM
  • syncytiotrophoblasts: 94 nCPM
  • plasma cells: 76 nCPM
  • extravillous trophoblasts: 73 nCPM
  • oocytes: 65 nCPM
  • hepatic stellate cells: 58 nCPM

Immune cell

  • eosinophil: 104 nTPM
  • basophil: 74 nTPM
  • plasmacytoid DC: 74 nTPM
  • NK-cell: 65 nTPM
  • total PBMC: 64 nTPM
  • myeloid DC: 63 nTPM

Brain region

  • medulla oblongata: 36 nTPM
  • hypothalamus: 32 nTPM
  • white matter: 32 nTPM
  • thalamus: 32 nTPM
  • cerebral cortex: 31 nTPM
  • spinal cord: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
-1.19
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PREB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PREB as an antibody target. Whether an autoantibody or antibody against PREB could matter depends on whether native PREB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PREB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PREB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PREB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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