Seroatlas · Human Serome Atlas

SEC63

Translocation protein SEC63 homolog

Also known as: DNAJC23, ERdj2, PRO2507, SEC63_HUMAN, SEC63L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UGP8
Gene
SEC63
Ensembl
ENSG00000025796
Chromosome
6
Canonical length
760 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

760 residues, UniProt reviewed canonical sequence.

>Q9UGP8|SEC63
     1  MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR KVYGRCMWYR
    61  LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY QEYNPYEVLN LDPGATVAEI
   121  KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA ALTDEESRKN WEEFGNPDGP QATSFGIALP
   181  AWIVDQKNSI LVLLVYGLAF MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN
   241  MDMKRLIMVL AGASEFDPQY NKDATSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK
   301  ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIVMARNR EEREFRAPTL
   361  ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN HKKYKIKTIQ DLVSLKESDR
   421  HTLLHFLEDE KYEEVMAVLG SFPYVTMDIK SQVLDDEDSN NITVGSLVTV LVKLTRQTMA
   481  EVFEKEQSIC AAEEQPAEDG QGETNKNRTK GGWQQKSKGP KKTAKSKKKK PLKKKPTPVL
   541  LPQSKQQKQK QANGVVGNEA AVKEDEEEVS DKGSDSEEEE TNRDSQSEKD DGSDRDSDRE
   601  QDEKQNKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW WWLYIADRKE
   661  QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS DSYMGLDQIK PLKLEVHEAK
   721  PVPENHPQWD TAIEGDEDQE DSEGFEDSFE EEEEEEEDDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 73 nTPM
  • pancreas: 58 nTPM
  • thyroid gland: 49 nTPM
  • liver: 44 nTPM
  • ovary: 32 nTPM
  • adrenal gland: 31 nTPM

Single-cell type

  • neutrophil progenitors: 452 nCPM
  • salivary acinar cells: 395 nCPM
  • pancreatic acinar cells: 325 nCPM
  • plasma cells: 291 nCPM
  • lacrimal acinar cells: 271 nCPM
  • gonadotrophs: 239 nCPM

Immune cell

  • non-classical monocyte: 9.9 nTPM
  • MAIT T-cell: 7.5 nTPM
  • NK-cell: 7.1 nTPM
  • plasmacytoid DC: 6.9 nTPM
  • basophil: 5.7 nTPM
  • myeloid DC: 5.4 nTPM

Brain region

  • choroid plexus: 60 nTPM
  • white matter: 41 nTPM
  • hypothalamus: 38 nTPM
  • cerebellum: 35 nTPM
  • medulla oblongata: 35 nTPM
  • basal ganglia: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SEC63.

Disease | AllUniProt

Conditions SEC63 is implicated in, by any mechanism.

  • Polycystic liver disease 2 with or without kidney cysts (PCLD2) MIM:617004

Disease | GeneticClinVar

60 pathogenic / likely-pathogenic of 564 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0
gnomAD missense Z
2.2
DepMap mean gene effect
-0.48
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC63 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC63 as an antibody target. Whether an autoantibody or antibody against SEC63 could matter depends on whether native SEC63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC63 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEC63. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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