Seroatlas · Human Serome Atlas

LMAN2

Vesicular integral-membrane protein VIP36

Also known as: C5orf8, GP36B, LMAN2_HUMAN, VIP36

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12907
Gene
LMAN2
Ensembl
ENSG00000169223
Chromosome
5
Canonical length
356 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q12907|LMAN2
     1  MAAEGWIWRW GWGRRCLGRP GLLGPGPGPT TPLFLLLLLG SVTADITDGN SEHLKREHSL
    61  IKPYQGVGSS SMPLWDFQGS TMLTSQYVRL TPDERSKEGS IWNHQPCFLK DWEMHVHFKV
   121  HGTGKKNLHG DGIALWYTRD RLVPGPVFGS KDNFHGLAIF LDTYPNDETT ERVFPYISVM
   181  VNNGSLSYDH SKDGRWTELA GCTADFRNRD HDTFLAVRYS RGRLTVMTDL EDKNEWKNCI
   241  DITGVRLPTG YYFGASAGTG DLSDNHDIIS MKLFQLMVEH TPDEESIDWT KIEPSVNFLK
   301  SPKDNVDDPT GNFRSGPLTG WRVFLLLLCA LLGIVVCAVV GAVVFQKRQE RNKRFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMAN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
213 nTPM

Expression across tissuesHPA

Tissue

  • liver: 213 nTPM
  • pancreas: 161 nTPM
  • esophagus: 152 nTPM
  • epididymis: 122 nTPM
  • choroid plexus: 115 nTPM
  • salivary gland: 107 nTPM

Single-cell type

  • syncytiotrophoblasts: 698 nCPM
  • extravillous trophoblasts: 615 nCPM
  • esophageal suprabasal cells: 594 nCPM
  • epididymal principal cells: 570 nCPM
  • esophageal apical cells: 568 nCPM
  • esophageal basal cells: 438 nCPM

Immune cell

  • total PBMC: 825 nTPM
  • basophil: 562 nTPM
  • neutrophil: 549 nTPM
  • plasmacytoid DC: 499 nTPM
  • eosinophil: 476 nTPM
  • classical monocyte: 410 nTPM

Brain region

  • choroid plexus: 78 nTPM
  • thalamus: 46 nTPM
  • medulla oblongata: 43 nTPM
  • hypothalamus: 40 nTPM
  • hippocampal formation: 39 nTPM
  • white matter: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMAN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMAN2 as an antibody target. Whether an autoantibody or antibody against LMAN2 could matter depends on whether native LMAN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMAN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMAN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LMAN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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