LRRC59
Leucine-rich repeat-containing protein 59
Also known as: FLJ21675, LRC59_HUMAN, PRO1855
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96AG4
- Gene
- LRRC59
- Ensembl
- ENSG00000108829
- Chromosome
- 17
- Canonical length
- 307 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Endoplasmic reticulum
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables RNA binding activity and cadherin binding activity. Predicted to be involved in intracellular signal transduction. Located in endoplasmic reticulum and mitochondrial nucleoid. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
307 residues, UniProt reviewed canonical sequence.
>Q96AG4|LRRC59
1 MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK LTTLPSDFCG
61 LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL PVSFAQLKNL KWLDLKDNPL
121 DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQRAK
181 EAQERELRKR EKAEEKERRR KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK
241 HTRSWAVLKL LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV
301 LQTDSQQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LRRC59 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 116 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 116 nTPM
- adrenal gland: 79 nTPM
- bone marrow: 75 nTPM
- liver: 71 nTPM
- stomach: 70 nTPM
- colon: 68 nTPM
Single-cell type
- extravillous trophoblasts: 356 nCPM
- syncytiotrophoblasts: 293 nCPM
- plasma cells: 166 nCPM
- esophageal basal cells: 162 nCPM
- late primary spermatocytes: 151 nCPM
- migrating cytotrophoblasts: 147 nCPM
Immune cell
- non-classical monocyte: 28 nTPM
- intermediate monocyte: 27 nTPM
- basophil: 23 nTPM
- classical monocyte: 22 nTPM
- myeloid DC: 20 nTPM
- eosinophil: 20 nTPM
Brain region
- thalamus: 34 nTPM
- cerebral cortex: 29 nTPM
- basal ganglia: 29 nTPM
- midbrain: 27 nTPM
- white matter: 27 nTPM
- choroid plexus: 26 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.55
- gnomAD pLI
- 0.43
- gnomAD missense Z
- 1.15
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LRRC59 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LRRC59 as an antibody target. Whether an autoantibody or antibody against LRRC59 could matter depends on whether native LRRC59 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LRRC59 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LRRC59 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...