Seroatlas · Human Serome Atlas

SEC61A2

Protein transport protein Sec61 subunit alpha isoform 2

Also known as: FLJ10578, S61A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H9S3
Gene
SEC61A2
Ensembl
ENSG00000065665
Chromosome
10
Canonical length
476 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q9H9S3|SEC61A2
     1  MGIKFLEVIK PFCAVLPEIQ KPERKIQFRE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD
    61  PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG
   121  MIITIGQAIV YVMTGMYGDP AEMGAGICLL IIIQLFVAGL IVLLLDELLQ KGYGLGSGIS
   181  LFIATNICET IVWKAFSPTT INTGRGTEFE GAVIALFHLL ATRTDKVRAL REAFYRQNLP
   241  NLMNLIATVF VFAVVIYFQG FRVDLPIKSA RYRGQYSSYP IKLFYTSNIP IILQSALVSN
   301  LYVISQMLSV RFSGNFLVNL LGQWADVSGG GPARSYPVGG LCYYLSPPES MGAIFEDPVH
   361  VVVYIIFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRDTSMV HELNRYIPTA
   421  AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQAEVGG MGALFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC61A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 32 nTPM
  • hypothalamus: 31 nTPM
  • cerebral cortex: 26 nTPM
  • hippocampal formation: 24 nTPM
  • cerebellum: 24 nTPM
  • midbrain: 22 nTPM

Single-cell type

  • neutrophils: 89 nCPM
  • retinal horizontal cells: 80 nCPM
  • other brain neurons: 63 nCPM
  • oligodendrocytes: 56 nCPM
  • brain inhibitory neurons: 56 nCPM
  • cardiomyocytes: 55 nCPM

Immune cell

  • plasmacytoid DC: 2.5 nTPM
  • neutrophil: 1.7 nTPM
  • naive CD4 T-cell: 1 nTPM
  • NK-cell: 0.9 nTPM
  • gdT-cell: 0.8 nTPM
  • MAIT T-cell: 0.7 nTPM

Brain region

  • white matter: 67 nTPM
  • cerebral cortex: 66 nTPM
  • hypothalamus: 64 nTPM
  • pons: 62 nTPM
  • midbrain: 61 nTPM
  • basal ganglia: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.01
gnomAD missense Z
3
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC61A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC61A2 as an antibody target. Whether an autoantibody or antibody against SEC61A2 could matter depends on whether native SEC61A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC61A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC61A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEC61A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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