Seroatlas · Human Serome Atlas

RPS26

Small ribosomal subunit protein eS26

Also known as: eS26, RS26_HUMAN, S26

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62854
Gene
RPS26
Ensembl
ENSG00000197728
Chromosome
12
Canonical length
115 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P62854|RPS26
     1  MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV RDISEASVFD
    61  AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR FRPAGAAPRP PPKPM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
1,250 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 1,250 nTPM
  • pancreas: 1,113 nTPM
  • ovary: 1,093 nTPM
  • liver: 885 nTPM
  • esophagus: 848 nTPM
  • skin: 824 nTPM

Single-cell type

  • gastric progenitor cells: 3,108 nCPM
  • epididymal efferent duct absorptive cells: 2,795 nCPM
  • extravillous trophoblasts: 2,740 nCPM
  • esophageal suprabasal cells: 2,577 nCPM
  • esophageal apical cells: 2,535 nCPM
  • ovarian stromal cells: 2,236 nCPM

Immune cell

  • total PBMC: 1,255 nTPM
  • T-reg: 965 nTPM
  • naive CD4 T-cell: 900 nTPM
  • memory B-cell: 874 nTPM
  • naive CD8 T-cell: 866 nTPM
  • memory CD4 T-cell: 843 nTPM

Brain region

  • hypothalamus: 136 nTPM
  • cerebral cortex: 111 nTPM
  • midbrain: 105 nTPM
  • medulla oblongata: 96 nTPM
  • thalamus: 92 nTPM
  • pons: 92 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS26.

Disease | AllUniProt

Conditions RPS26 is implicated in, by any mechanism.

Disease | GeneticClinVar

34 pathogenic / likely-pathogenic of 188 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.85
gnomAD missense Z
1.93

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS26 as an antibody target. Whether an autoantibody or antibody against RPS26 could matter depends on whether native RPS26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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