Seroatlas · Human Serome Atlas

RPS9

Small ribosomal subunit protein uS4

Also known as: RS9_HUMAN, S9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46781
Gene
RPS9
Ensembl
ENSG00000170889
Chromosome
19
Canonical length
194 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>P46781|RPS9
     1  MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL
    61  LTLDEKDPRR LFEGNALLRR LVRIGVLDEG KMKLDYILGL KIEDFLERRL QTQVFKLGLA
   121  KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR LDSQKHIDFS LRSPYGGGRP GRVKRKNAKK
   181  GQGGAGAGDD EEED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
2,914 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2,914 nTPM
  • pancreas: 2,767 nTPM
  • skin: 2,213 nTPM
  • esophagus: 1,806 nTPM
  • breast: 1,635 nTPM
  • cervix: 1,602 nTPM

Single-cell type

  • breast secretory cells: 4,913 nCPM
  • decidual stromal cells: 4,707 nCPM
  • suprabasal keratinocytes: 4,443 nCPM
  • basal keratinocytes: 4,088 nCPM
  • epididymal basal cells: 3,791 nCPM
  • enteric stem cells: 3,788 nCPM

Immune cell

  • total PBMC: 2,878 nTPM
  • naive CD4 T-cell: 1,252 nTPM
  • naive B-cell: 1,123 nTPM
  • memory B-cell: 1,074 nTPM
  • naive CD8 T-cell: 1,069 nTPM
  • plasmacytoid DC: 1,021 nTPM

Brain region

  • midbrain: 69 nTPM
  • medulla oblongata: 54 nTPM
  • thalamus: 40 nTPM
  • white matter: 36 nTPM
  • pons: 30 nTPM
  • hippocampal formation: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.88
gnomAD missense Z
2.73
DepMap mean gene effect
-1.75
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS9 as an antibody target. Whether an autoantibody or antibody against RPS9 could matter depends on whether native RPS9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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