RILP

Protein identityUniProt · HPA

UniProt accession

Q96NA2

Gene

RILP

Ensembl

ENSG00000167705

Chromosome

17

Canonical length

401 aa

Protein class

Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q96NA2|RILP
     1  MEPRRAAPGV PGWGSREAAG SASAAELVYH LAGALGTELQ DLARRFGPEA AAGLVPLVVR
    61  ALELLEQAAV GPAPDSLQVS AQPAEQELRR LREENERLRR ELRAGPQEER ALLRQLKEVT
   121  DRQRDELRAH NRDLRQRGQE TEALQEQLQR LLLVNAELRH KLAAMQTQLR AAQDRERERQ
   181  QPGEAATPQA KERARGQAGR PGHQHGQEPE WATAGAGAPG NPEDPAEAAQ QLGRPSEAGQ
   241  CRFSREEFEQ ILQERNELKA KVFLLKEELA YFQRELLTDH RVPGLLLEAM KVAVRKQRKK
   301  IKAKMLGTPE EAESSEDEAG PWILLSDDKG DHPPPPESKI QSFFGLWYRG KAESSEDETS
   361  SPAPSKLGGE EEAQPQSPAP DPPCSALHEH LCLGASAAPE A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RILP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

65 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.69

gnomAD pLI

0

gnomAD missense Z

-0.02

DepMap mean gene effect

-0.31

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cilium assembly
• early endosome to late endosome transport
• endosome to lysosome transport
• endosome transport via multivesicular body sorting pathway
• intralumenal vesicle formation
• negative regulation of protein catabolic process
• positive regulation of protein catabolic process
• protein transport

Molecular functions

• dynein light intermediate chain binding
• protein dimerization activity
• small GTPase binding

Cellular components

• ciliary basal body
• cytoplasm
• late endosome
• late endosome membrane
• lysosomal membrane
• lysosome
• phagocytic vesicle membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Rab interacting lysosomal protein, dimerization domain
• RH1 domain
• RH2 domain
• DZIP and RILPL
• RILP homology 1 domain
• Rab interacting lysosomal protein

KeywordsUniProt

• Coiled coil
• Cytoplasmic vesicle
• Endosome
• Lysosome
• Membrane
• Phosphoprotein
• Protein transport
• Transport

InteractionsUniProt · HPA

Protein binding partners of RILP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CLN3
• FLCN
• MREG
• RAB34
• RAB7A
• VPS41