Seroatlas · Human Serome Atlas

LAMTOR2

Ragulator complex protein LAMTOR2

Also known as: ENDAP, LTOR2_HUMAN, MAPBPIP, MAPKSP1AP, p14, Ragulator2, ROBLD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2Q5
Gene
LAMTOR2
Ensembl
ENSG00000116586
Chromosome
1
Canonical length
125 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q9Y2Q5|LAMTOR2
     1  MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS NIWAAYDRNG
    61  NQAFNEDNLK FILMDCMEGR VAITRVANLL LCMYAKETVG FGMLKAKAQA LVQYLEEPLT
   121  QVAAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAMTOR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
169 nTPM

Expression across tissuesHPA

Tissue

  • liver: 169 nTPM
  • choroid plexus: 109 nTPM
  • kidney: 103 nTPM
  • heart muscle: 98 nTPM
  • skeletal muscle: 92 nTPM
  • pancreas: 91 nTPM

Single-cell type

  • hofbauer cells: 577 nCPM
  • esophageal apical cells: 402 nCPM
  • esophageal suprabasal cells: 365 nCPM
  • hepatocytes: 361 nCPM
  • gastric progenitor cells: 292 nCPM
  • parietal cells: 285 nCPM

Immune cell

  • myeloid DC: 538 nTPM
  • classical monocyte: 467 nTPM
  • intermediate monocyte: 448 nTPM
  • total PBMC: 390 nTPM
  • eosinophil: 378 nTPM
  • non-classical monocyte: 365 nTPM

Brain region

  • thalamus: 40 nTPM
  • white matter: 39 nTPM
  • hypothalamus: 38 nTPM
  • cerebellum: 35 nTPM
  • choroid plexus: 33 nTPM
  • midbrain: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LAMTOR2.

Disease | AllUniProt

Conditions LAMTOR2 is implicated in, by any mechanism.

  • Immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP) MIM:610798

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.2
gnomAD missense Z
1.26
DepMap mean gene effect
-0.59
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAMTOR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAMTOR2 as an antibody target. Whether an autoantibody or antibody against LAMTOR2 could matter depends on whether native LAMTOR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAMTOR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LAMTOR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LAMTOR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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