Seroatlas · Human Serome Atlas

ATP6V0D1

V-type proton ATPase subunit d 1

Also known as: ATP6D, ATP6DV, P39, VA0D1_HUMAN, VATX, Vma6, VPATPD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61421
Gene
ATP6V0D1
Ensembl
ENSG00000159720
Chromosome
16
Canonical length
351 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>P61421|ATP6V0D1
     1  MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ STDYGNFLAN
    61  EASPLTVSVI DDRLKEKMVV EFRHMRNHAY EPLASFLDFI TYSYMIDNVI LLITGTLHQR
   121  SIAELVPKCH PLGSFEQMEA VNIAQTPAEL YNAILVDTPL AAFFQDCISE QDLDEMNIEI
   181  IRNTLYKAYL ESFYKFCTLL GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL
   241  FPHCGRLYPE GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK
   301  LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6V0D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
135 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 135 nTPM
  • skeletal muscle: 128 nTPM
  • choroid plexus: 121 nTPM
  • hypothalamus: 116 nTPM
  • adrenal gland: 113 nTPM
  • parathyroid gland: 110 nTPM

Single-cell type

  • neutrophils: 667 nCPM
  • syncytiotrophoblasts: 418 nCPM
  • hofbauer cells: 364 nCPM
  • monocytes: 283 nCPM
  • esophageal apical cells: 243 nCPM
  • colonocytes: 227 nCPM

Immune cell

  • neutrophil: 941 nTPM
  • total PBMC: 743 nTPM
  • classical monocyte: 734 nTPM
  • eosinophil: 544 nTPM
  • intermediate monocyte: 512 nTPM
  • non-classical monocyte: 488 nTPM

Brain region

  • hypothalamus: 227 nTPM
  • pons: 210 nTPM
  • hippocampal formation: 172 nTPM
  • cerebral cortex: 166 nTPM
  • midbrain: 149 nTPM
  • medulla oblongata: 143 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
2.93
DepMap mean gene effect
-1.34
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP6V0D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP6V0D1 as an antibody target. Whether an autoantibody or antibody against ATP6V0D1 could matter depends on whether native ATP6V0D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP6V0D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP6V0D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATP6V0D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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