Seroatlas · Human Serome Atlas

MON1A

Vacuolar fusion protein MON1 homolog A

Also known as: MGC13272, MON1A_HUMAN, SAND1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VX9
Gene: MON1A
Ensembl: ENSG00000164077
Chromosome: 3
Canonical length: 652 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in protein secretion. Predicted to act upstream of or within establishment of localization in cell; intracellular iron ion homeostasis; and protein transport. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q86VX9|MON1A
     1  MHPGGGPSRA ERLELGLGRE RPAKAIFLHR RPGEGGGRER CLRCGHVCVR RGPGPREAVP
    61  SGRPRPDTLT PPWVRQRAVT GTFCASWTPL RNRRAQRMAT DMQRKRSSEC LDGTLTPSDG
   121  QSMERAESPT PGMAQGMEPG AGQEGAMFVH ARSYEDLTES EDGAASGDSH KEGTRGPPPL
   181  PTDMRQISQD FSELSTQLTG VARDLQEEML PGSSEDWLEP PGAVGRPATE PPREGTTEGD
   241  EEDATEAWRL HQKHVFVLSE AGKPVYSRYG SEEALSSTMG VMVALVSFLE ADKNAIRSIH
   301  ADGYKVVFVR RSPLVLVAVA RTRQSAQELA QELLYIYYQI LSLLTGAQLS HIFQQKQNYD
   361  LRRLLSGSER ITDNLLQLMA RDPSFLMGAA RCLPLAAAVR DTVSASLQQA RARSLVFSIL
   421  LARNQLVALV RRKDQFLHPI DLHLLFNLIS SSSSFREGEA WTPVCLPKFN AAGFFHAHIS
   481  YLEPDTDLCL LLVSTDREDF FAVSDCRRRF QERLRKRGAH LALREALRTP YYSVAQVGIP
   541  DLRHFLYKSK SSGLFTSPEI EAPYTSEEEQ ERLLGLYQYL HSRAHNASRP LKTIYYTGPN
   601  ENLLAWVTGA FELYMCYSPL GTKASAVSAI HKLMRWIRKE EDRLFILTPL TY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MON1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 19 nTPM
duodenum: 17 nTPM
skeletal muscle: 15 nTPM
amygdala: 15 nTPM
hippocampal formation: 14 nTPM
testis: 14 nTPM

Single-cell type

oocytes: 184 nCPM
late spermatids: 60 nCPM
late primary spermatocytes: 22 nCPM
esophageal basal cells: 19 nCPM
early spermatids: 18 nCPM
retinal pigment epithelial cells: 17 nCPM

Immune cell

NK-cell: 19 nTPM
MAIT T-cell: 17 nTPM
naive CD4 T-cell: 15 nTPM
memory CD8 T-cell: 15 nTPM
gdT-cell: 15 nTPM
T-reg: 14 nTPM

Brain region

cerebral cortex: 20 nTPM
basal ganglia: 18 nTPM
amygdala: 17 nTPM
pons: 17 nTPM
hippocampal formation: 17 nTPM
midbrain: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MON1A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 100 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Congenital diarrhea

Disease | ImmuneIEDB

Conditions an epitope on MON1A was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 1.89
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MON1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MON1A as an antibody target. Whether an autoantibody or antibody against MON1A could matter depends on whether native MON1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MON1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MON1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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