Seroatlas · Human Serome Atlas

RIMOC1

RAB7A-interacting MON1-CCZ1 complex subunit 1

Also known as: C5orf51, LOC285636, RIMC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NDU8
Gene: RIMOC1
Ensembl: ENSG00000205765
Chromosome: 5
Canonical length: 294 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in mitophagy. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>A6NDU8|RIMOC1
     1  MAAAVSSVVR RVEELGDLAQ AHIQQLSEAA GEDDHFLIRA SAALEKLKLL CGEEKECSNP
    61  SNLLELYTQA ILDMTYFEEN KLVDEDFPED SSSQKVKELI SFLSEPEILV KENNMHPKHC
   121  NLLGDELLEC LSWRRGALLY MYCHSLTKRR EWLLRKSSLL KKYLLDGISY LLQMLNYRCP
   181  IQLNEGVSFQ DLDTAKLLSA GIFSDIHLLA MMYSGEMCYW GSKYCADQQP ENHEVDTSVS
   241  GAGCTTYKEP LDFREVGEKI LKKYVSVCEG PLKEQEWNTT NAKQILNFFH HRCN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIMOC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

thymus: 15 nTPM
epididymis: 15 nTPM
retina: 15 nTPM
parathyroid gland: 14 nTPM
thyroid gland: 13 nTPM
placenta: 12 nTPM

Single-cell type

epididymal principal cells: 54 nCPM
esophageal apical cells: 36 nCPM
parietal cells: 32 nCPM
megakaryocytes: 31 nCPM
schwann cells: 28 nCPM
hofbauer cells: 25 nCPM

Immune cell

basophil: 26 nTPM
total PBMC: 7.5 nTPM
non-classical monocyte: 7.3 nTPM
classical monocyte: 6.9 nTPM
eosinophil: 6.8 nTPM
myeloid DC: 6.4 nTPM

Brain region

white matter: 35 nTPM
basal ganglia: 28 nTPM
cerebellum: 28 nTPM
midbrain: 28 nTPM
medulla oblongata: 27 nTPM
hypothalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitophagy

Cellular components

Protein domainsUniProt · Pfam · InterPro

RAB7A-interacting MON1-CCZ1 complex subunit 1
RAB7A-interacting MON1-CCZ1 complex subunit 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIMOC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIMOC1 as an antibody target. Whether an autoantibody or antibody against RIMOC1 could matter depends on whether native RIMOC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIMOC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIMOC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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