CCZ1
Vacuolar fusion protein CCZ1 homolog
Also known as: C7orf28A, CCZ1_HUMAN, CCZ1A, CGI-43
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P86791
- Gene
- CCZ1
- Ensembl
- ENSG00000122674
- Chromosome
- 7
- Canonical length
- 482 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
482 residues, UniProt reviewed canonical sequence.
>P86791|CCZ1
1 MAAAAAGAGS GPWAAQEKQF PPALLSFFIY NPRFGPREGQ EENKILFYHP NEVEKNEKIR
61 NVGLCEAIVQ FTRTFSPSKP AKSLHTQKNR QFFNEPEENF WMVMVVRNPI IEKQSKDGKP
121 VIEYQEEELL DKVYSSVLRQ CYSMYKLFNG TFLKAMEDGG VKLLKERLEK FFHRYLQTLH
181 LQSCDLLDIF GGISFFPLDK MTYLKIQSFI NRMEESLNIV KYTAFLYNDQ LIWSGLEQDD
241 MRILYKYLTT SLFPRHIEPE LAGRDSPIRA EMPGNLQHYG RFLTGPLNLN DPDAKCRFPK
301 IFVNTDDTYE ELHLIVYKAM SAAVCFMIDA SVHPTLDFCR RLDSIVGPQL TVLASDICEQ
361 FNINKRMSGS EKEPQFKFIY FNHMNLAEKS TVHMRKTPSV SLTSVHPDLM KILGDINSDF
421 TRVDEDEEII VKAMSDYWVV GKKSDRRELY VILNQKNANL IEVNEEVKKL CATQFNNIFF
481 LDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 28 nTPM
- bone marrow: 25 nTPM
- adrenal gland: 21 nTPM
- thymus: 19 nTPM
- urinary bladder: 19 nTPM
- heart muscle: 17 nTPM
Single-cell type
- esophageal apical cells: 99 nCPM
- gastric progenitor cells: 63 nCPM
- adrenal cortex cells: 57 nCPM
- foveolar cells: 54 nCPM
- cytotrophoblasts: 52 nCPM
- hepatic stellate cells: 52 nCPM
Immune cell
- T-reg: 4.2 nTPM
- NK-cell: 2.7 nTPM
- eosinophil: 2.3 nTPM
- non-classical monocyte: 2.3 nTPM
- intermediate monocyte: 2.2 nTPM
- memory CD8 T-cell: 2 nTPM
Brain region
- choroid plexus: 16 nTPM
- cerebellum: 13 nTPM
- cerebral cortex: 12 nTPM
- hippocampal formation: 12 nTPM
- white matter: 12 nTPM
- hypothalamus: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.92
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.19
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CCZ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCZ1 as an antibody target. Whether an autoantibody or antibody against CCZ1 could matter depends on whether native CCZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCZ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CCZ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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