RABAC1
Prenylated Rab acceptor protein 1
Also known as: PRA1, PRAF1, PRAF1_HUMAN, YIP3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UI14
- Gene
- RABAC1
- Ensembl
- ENSG00000105404
- Chromosome
- 19
- Canonical length
- 185 aa
- Protein class
- Predicted membrane proteins, Transporters
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables identical protein binding activity. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
185 residues, UniProt reviewed canonical sequence.
>Q9UI14|RABAC1
1 MAAQKDQQKD AEAEGLSGTT LLPKLIPSGA GREWLERRRA TIRPWSTFVD QQRFSRPRNL
61 GELCQRLVRN VEYYQSNYVF VFLGLILYCV VTSPMLLVAL AVFFGACYIL YLRTLESKLV
121 LFGREVSPAH QYALAGGISF PFFWLAGAGS AVFWVLGATL VVIGSHAAFH QIEAVDGEEL
181 QMEPVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RABAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 368 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 368 nTPM
- pituitary gland: 252 nTPM
- hypothalamus: 239 nTPM
- midbrain: 234 nTPM
- endometrium: 229 nTPM
- amygdala: 223 nTPM
Single-cell type
- late spermatids: 1,139 nCPM
- plasma cells: 713 nCPM
- extravillous trophoblasts: 661 nCPM
- decidual stromal cells: 631 nCPM
- hepatic stellate cells: 478 nCPM
- goblet cells: 439 nCPM
Immune cell
- neutrophil: 779 nTPM
- basophil: 723 nTPM
- eosinophil: 553 nTPM
- total PBMC: 511 nTPM
- plasmacytoid DC: 411 nTPM
- T-reg: 405 nTPM
Brain region
- medulla oblongata: 213 nTPM
- hypothalamus: 210 nTPM
- pons: 206 nTPM
- thalamus: 202 nTPM
- white matter: 200 nTPM
- spinal cord: 184 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.07
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.74
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RABAC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RABAC1 as an antibody target. Whether an autoantibody or antibody against RABAC1 could matter depends on whether native RABAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RABAC1 is annotated at the cell surface, where native RABAC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RABAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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