Seroatlas · Human Serome Atlas

NTRK1

High affinity nerve growth factor receptor

Also known as: MTC, NTRK1_HUMAN, TRK, TRKA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04629
Gene
NTRK1
Ensembl
ENSG00000198400
Chromosome
1
Canonical length
796 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Subcellular location
Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

796 residues, UniProt reviewed canonical sequence.

>P04629|NTRK1
     1  MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC TRDGALDSLH
    61  HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSRL
   121  NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ
   181  GPLAHMPNAS CGVPTLKVQV PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK
   241  SGGLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSVQV NVSFPASVQL HTAVEMHHWC
   301  IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPAANET VRHGCLRLNQ PTHVNNGNYT
   361  LLAANPFGQA SASIMAAFMD NPFEFNPEDP IPVSFSPVDT NSTSGDPVEK KDETPFGVSV
   421  AVGLAVFACL FLSTLLLVLN KCGRRNKFGI NRPAVLAPED GLAMSLHFMT LGGSSLSPTE
   481  GKGSGLQGHI IENPQYFSDA CVHHIKRRDI VLKWELGEGA FGKVFLAECH NLLPEQDKML
   541  VAVKALKEAS ESARQDFQRE AELLTMLQHQ HIVRFFGVCT EGRPLLMVFE YMRHGDLNRF
   601  LRSHGPDAKL LAGGEDVAPG PLGLGQLLAV ASQVAAGMVY LAGLHFVHRD LATRNCLVGQ
   661  GLVVKIGDFG MSRDIYSTDY YRVGGRTMLP IRWMPPESIL YRKFTTESDV WSFGVVLWEI
   721  FTYGKQPWYQ LSNTEAIDCI TQGRELERPR ACPPEVYAIM RGCWQREPQQ RHSIKDVHAR
   781  LQALAQAPPV YLDVLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTRK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
6.6 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 6.6 nTPM
  • kidney: 3.5 nTPM
  • basal ganglia: 3 nTPM
  • prostate: 2 nTPM
  • retina: 1.9 nTPM
  • testis: 1.7 nTPM

Single-cell type

  • retinal horizontal cells: 52 nCPM
  • retinal bipolar cells: 50 nCPM
  • mast cells: 35 nCPM
  • adrenal medulla cells: 32 nCPM
  • fibro-adipogenic progenitors: 21 nCPM
  • decidual stromal cells: 20 nCPM

Immune cell

  • basophil: 95 nTPM
  • eosinophil: 0.8 nTPM
  • neutrophil: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • pons: 48 nTPM
  • medulla oblongata: 31 nTPM
  • cerebral cortex: 24 nTPM
  • hypothalamus: 7.4 nTPM
  • cerebellum: 5.7 nTPM
  • basal ganglia: 5.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NTRK1.

Disease | AllUniProt

Conditions NTRK1 is implicated in, by any mechanism.

  • Congenital insensitivity to pain with anhidrosis (CIPA) MIM:256800

Disease | GeneticClinVar

201 pathogenic / likely-pathogenic of 1,565 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
1.03
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NTRK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTRK1 as an antibody target. Whether an autoantibody or antibody against NTRK1 could matter depends on whether native NTRK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTRK1 is annotated at the cell surface, where native NTRK1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NTRK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NTRK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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