Seroatlas · Human Serome Atlas

POLR1C

DNA-directed RNA polymerases I and III subunit RPAC1

Also known as: AC40, RPA39, RPA40, RPA5, RPAC1, RPAC1_HUMAN, RPC40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15160
Gene
POLR1C
Ensembl
ENSG00000171453
Chromosome
6
Canonical length
346 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>O15160|POLR1C
     1  MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS
    61  LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR
   121  LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN
   181  QADLFPEGTI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT
   241  LLEPVEGEAA EELSRCFSPG VIEVQEVQGK KVARVANPRL DTFSREIFRN EKLKKVVRLA
   301  RVRDHYIFSV ESTGVLPPDV LVSEAIKVLM GKCRRFLDEL DAVQMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 25 nTPM
  • urinary bladder: 22 nTPM
  • esophagus: 20 nTPM
  • fallopian tube: 20 nTPM
  • testis: 20 nTPM
  • tonsil: 20 nTPM

Single-cell type

  • epicardial cells: 237 nCPM
  • cardiomyocytes: 206 nCPM
  • differentiating spermatogonia: 97 nCPM
  • basal keratinocytes: 78 nCPM
  • respiratory ciliated cells: 74 nCPM
  • oocytes: 69 nCPM

Immune cell

  • naive B-cell: 55 nTPM
  • naive CD4 T-cell: 55 nTPM
  • memory B-cell: 51 nTPM
  • naive CD8 T-cell: 50 nTPM
  • MAIT T-cell: 47 nTPM
  • myeloid DC: 42 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • white matter: 11 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 10 nTPM
  • pons: 10 nTPM
  • thalamus: 9.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POLR1C.

Disease | AllUniProt

Conditions POLR1C is implicated in, by any mechanism.

Disease | GeneticClinVar

51 pathogenic / likely-pathogenic of 287 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0
gnomAD missense Z
-1.44
DepMap mean gene effect
-1.71
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLR1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR1C as an antibody target. Whether an autoantibody or antibody against POLR1C could matter depends on whether native POLR1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POLR1C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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