NME1
Nucleoside diphosphate kinase A
Also known as: NDKA_HUMAN, NDPKA, NM23, NM23-H1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P15531
- Gene
- NME1
- Ensembl
- ENSG00000239672
- Chromosome
- 17
- Canonical length
- 152 aa
- Protein class
- Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
- Quaternary structure
- Homohexamer
OverviewNCBI Gene
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
152 residues, UniProt reviewed canonical sequence.
>P15531|NME1
1 MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF
61 FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS
121 DSVESAEKEI GLWFHPEELV DYTSCAQNWI YELocalizationUniProt · AlphaFold · HPA
Whether an antibody against NME1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 203 nTPM
Expression across tissuesHPA
Tissue
- retina: 203 nTPM
- choroid plexus: 145 nTPM
- cerebral cortex: 130 nTPM
- hippocampal formation: 122 nTPM
- hypothalamus: 118 nTPM
- amygdala: 110 nTPM
Single-cell type
- differentiating spermatogonia: 108 nCPM
- late spermatids: 103 nCPM
- gastric progenitor cells: 99 nCPM
- migrating cytotrophoblasts: 97 nCPM
- megakaryocyte progenitors: 91 nCPM
- decidual stromal cells: 89 nCPM
Immune cell
- myeloid DC: 134 nTPM
- memory B-cell: 97 nTPM
- plasmacytoid DC: 85 nTPM
- intermediate monocyte: 77 nTPM
- NK-cell: 70 nTPM
- MAIT T-cell: 70 nTPM
Brain region
- hypothalamus: 80 nTPM
- hippocampal formation: 70 nTPM
- medulla oblongata: 62 nTPM
- cerebral cortex: 62 nTPM
- pons: 60 nTPM
- basal ganglia: 56 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.21
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.54
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- acetyl-CoA catabolic process
- apoptotic DNA fragmentation
- cell differentiation
- CTP biosynthetic process
- DNA catabolic process
- endocytosis
- GTP biosynthetic process
- isoprenoid metabolic process
- ITP biosynthetic process
- lactation
- negative regulation of cell population proliferation
- nervous system development
- nucleoside diphosphate metabolic process
- nucleoside triphosphate biosynthetic process
- positive regulation of epithelial cell proliferation
- protein hexamerization
- regulation of apoptotic process
- regulation of fatty acid biosynthetic process
- UTP biosynthetic process
Molecular functions
- 3'-5'-DNA exonuclease activity
- acetyl-CoA binding
- ADP binding
- ATP binding
- coenzyme A binding
- DNA binding
- DNA endonuclease activity
- DNA nuclease activity
- GDP binding
- identical protein binding
- kinase activity
- magnesium ion binding
- nucleoside diphosphate kinase activity
- protein histidine kinase activity
- ribosomal small subunit binding
- RNA binding
- farnesyl diphosphate kinase activity
- phosphotransferase activity, phosphate group as acceptor
- succinyl-CoA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NME1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NME1 as an antibody target. Whether an autoantibody or antibody against NME1 could matter depends on whether native NME1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NME1 is annotated at the cell surface, where native NME1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label NME1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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