Seroatlas · Human Serome Atlas

POLR1F

DNA-directed RNA polymerase I subunit RPA43

Also known as: A43, RPA43, RPA43_HUMAN, TWISTNB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3B726
Gene
POLR1F
Ensembl
ENSG00000105849
Chromosome
7
Canonical length
338 aa
Protein class
Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to be involved in transcription elongation by RNA polymerase I. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Part of RNA polymerase I complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q3B726|POLR1F
     1  MAAGCSEAPR PAAASDGSLV GQAGVLPCLE LPTYAAACAL VNSRYSCLVA GPHQRHIALS
    61  PRYLNRKRTG IREQLDAELL RYSESLLGVP IAYDNIKVVG ELGDIYDDQG HIHLNIEADF
   121  VIFCPEPGQK LMGIVNKVSS SHIGCLVHGC FNASIPKPEQ LSAEQWQTME INMGDELEFE
   181  VFRLDSDAAG VFCIRGKLNI TSLQFKRSEV SEEVTENGTE EAAKKPKKKK KKKDPETYEV
   241  DSGTTKLADD ADDTPMEESA LQNTNNANGI WEEEPKKKKK KKKHQEVQDQ DPVFQGSDSS
   301  GYQSDHKKKK KKRKHSEEAE FTPPLKCSPK RKGKSNFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR1F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 16 nTPM
  • tonsil: 12 nTPM
  • urinary bladder: 11 nTPM
  • endometrium: 11 nTPM
  • smooth muscle: 11 nTPM
  • placenta: 10 nTPM

Single-cell type

  • decidual stromal cells: 211 nCPM
  • endometrial stromal cells: 191 nCPM
  • endometrial luminal cells: 182 nCPM
  • monocytes: 157 nCPM
  • oocytes: 143 nCPM
  • suprabasal keratinocytes: 130 nCPM

Immune cell

  • NK-cell: 18 nTPM
  • naive B-cell: 13 nTPM
  • naive CD8 T-cell: 13 nTPM
  • memory B-cell: 13 nTPM
  • MAIT T-cell: 12 nTPM
  • naive CD4 T-cell: 11 nTPM

Brain region

  • white matter: 11 nTPM
  • hypothalamus: 9.3 nTPM
  • midbrain: 9.3 nTPM
  • spinal cord: 8.8 nTPM
  • cerebral cortex: 8.2 nTPM
  • basal ganglia: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.62
DepMap mean gene effect
-2.05
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLR1F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR1F as an antibody target. Whether an autoantibody or antibody against POLR1F could matter depends on whether native POLR1F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR1F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR1F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POLR1F. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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