Seroatlas · Human Serome Atlas

CRCP

DNA-directed RNA polymerase III subunit RPC9

Also known as: C17, CGRP-RCP, POLR3I, RCP, RCP9, RPC9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75575
Gene: CRCP
Ensembl: ENSG00000241258
Chromosome: 7
Canonical length: 148 aa
Protein class: Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>O75575|CRCP
     1  MEVKDANSAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCRH
    61  QSPEIVREFL TALKSHKLTK AEKLQLLNHR PVTAVEIQLM VEESEERLTE EQIEALLHTV
   121  TSILPAEPEA EQKKNTNSNV AMDEEDPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRCP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 35 nTPM
liver: 33 nTPM
parathyroid gland: 20 nTPM
pancreas: 19 nTPM
esophagus: 19 nTPM
thyroid gland: 19 nTPM

Single-cell type

breast lactating cells: 47 nCPM
pancreatic acinar cells: 40 nCPM
choroid plexus epithelial cells: 34 nCPM
microglia: 34 nCPM
brain excitatory neurons: 32 nCPM
brain inhibitory neurons: 31 nCPM

Immune cell

basophil: 26 nTPM
neutrophil: 21 nTPM
eosinophil: 21 nTPM
gdT-cell: 18 nTPM
naive CD8 T-cell: 17 nTPM
MAIT T-cell: 17 nTPM

Brain region

pons: 30 nTPM
hypothalamus: 29 nTPM
cerebellum: 26 nTPM
midbrain: 26 nTPM
white matter: 26 nTPM
medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -1.41
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNA polymerase subunit Rpb4/RPC9
RNA polymerase Rpb4/RPC9, core
HRDC-like superfamily
Rpb4/RPC9 superfamily
RNA polymerase Rpb4
DNA-directed RNA polymerase III subunit RPC9

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRCP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRCP as an antibody target. Whether an autoantibody or antibody against CRCP could matter depends on whether native CRCP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRCP is annotated at the cell surface, where native CRCP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CRCP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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