POLR3K
DNA-directed RNA polymerase III subunit RPC10
Also known as: C11, RPC10_HUMAN, RPC11
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y2Y1
- Gene
- POLR3K
- Ensembl
- ENSG00000161980
- Chromosome
- 16
- Canonical length
- 108 aa
- Protein class
- Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]
Canonical amino-acid sequenceUniProt
108 residues, UniProt reviewed canonical sequence.
>Q9Y2Y1|POLR3K
1 MLLFCPGCGN GLIVEEGQRC HRFACNTCPY VHNITRKVTN RKYPKLKEVD DVLGGAAAWE
61 NVDSTAESCP KCEHPRAYFM QLQTRSADEP MTTFYKCCNA QCGHRWRDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against POLR3K can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 19 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 19 nTPM
- lymph node: 17 nTPM
- tonsil: 15 nTPM
- cerebral cortex: 14 nTPM
- basal ganglia: 13 nTPM
- appendix: 12 nTPM
Single-cell type
- gastric progenitor cells: 88 nCPM
- esophageal basal cells: 76 nCPM
- megakaryocytes: 74 nCPM
- migrating cytotrophoblasts: 55 nCPM
- extravillous trophoblasts: 54 nCPM
- cytotrophoblasts: 51 nCPM
Immune cell
- memory B-cell: 115 nTPM
- naive B-cell: 111 nTPM
- eosinophil: 94 nTPM
- T-reg: 88 nTPM
- plasmacytoid DC: 70 nTPM
- intermediate monocyte: 55 nTPM
Brain region
- hypothalamus: 17 nTPM
- white matter: 15 nTPM
- cerebral cortex: 15 nTPM
- basal ganglia: 15 nTPM
- hippocampal formation: 14 nTPM
- cerebellum: 14 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about POLR3K.
Disease | AllUniProt
Conditions POLR3K is implicated in, by any mechanism.
- Leukodystrophy, hypomyelinating, 21 (HLD21) MIM:619310
Disease | GeneticClinVar
3 pathogenic / likely-pathogenic of 25 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Leukodystrophy, hypomyelinating, 21
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.23
- gnomAD pLI
- 0.11
- gnomAD missense Z
- -0.09
- DepMap mean gene effect
- -1.45
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Zinc finger, TFIIS-type
- DNA-directed RNA polymerase II subunit RPB9-like, zinc ribbon
- DNA-directed RNA polymerase subunit/transcription factor S
- DNA-directed RNA polymerase M, 15kDa subunit, conserved site
- Transcription factor S-II (TFIIS)
- RNA polymerases M/15 Kd subunit
- Pol III subunit C11, C-terminal zinc ribbon
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of POLR3K in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads POLR3K as an antibody target. Whether an autoantibody or antibody against POLR3K could matter depends on whether native POLR3K is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
POLR3K is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label POLR3K as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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