Seroatlas · Human Serome Atlas

POLR3E

DNA-directed RNA polymerase III subunit RPC5

Also known as: C37, FLJ10509, RPC5, RPC5_HUMAN, SIN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVU0
Gene: POLR3E
Ensembl: ENSG00000058600
Chromosome: 16
Canonical length: 708 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in DNA-templated transcription; defense response to virus; and innate immune response. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

708 residues, UniProt reviewed canonical sequence.

>Q9NVU0|POLR3E
     1  MANEEDDPVV QEIDVYLAKS LAEKLYLFQY PVRPASMTYD DIPHLSAKIK PKQQKVELEM
    61  AIDTLNPNYC RSKGEQIALN VDGACADETS TYSSKLMDKQ TFCSSQTTSN TSRYAAALYR
   121  QGELHLTPLH GILQLRPSFS YLDKADAKHR EREAANEAGD SSQDEAEDDV KQITVRFSRP
   181  ESEQARQRRV QSYEFLQKKH AEEPWVHLHY YGLRDSRSEH ERQYLLCPGS SGVENTELVK
   241  SPSEYLMMLM PPSQEEEKDK PVAPSNVLSM AQLRTLPLAD QIKILMKNVK VMPFANLMSL
   301  LGPSIDSVAV LRGIQKVAML VQGNWVVKSD ILYPKDSSSP HSGVPAEVLC RGRDFVMWKF
   361  TQSRWVVRKE VATVTKLCAE DVKDFLEHMA VVRINKGWEF ILPYDGEFIK KHPDVVQRQH
   421  MLWTGIQAKL EKVYNLVKET MPKKPDAQSG PAGLVCGDQR IQVAKTKAQQ NHALLERELQ
   481  RRKEQLRVPA VPPGVRIKEE PVSEEGEEDE EQEAEEEPMD TSPSGLHSKL ANGLPLGRAA
   541  GTDSFNGHPP QGCASTPVAR ELKAFVEATF QRQFVLTLSE LKRLFNLHLA SLPPGHTLFS
   601  GISDRMLQDT VLAAGCKQIL VPFPPQTAAS PDEQKVFALW ESGDMSDQHR QVLLEIFSKN
   661  YRVRRNMIQS RLTQECGEDL SKQEVDKVLK DCCVSYGGMW YLKGTVQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR3E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 56 nTPM
choroid plexus: 17 nTPM
adrenal gland: 16 nTPM
pancreas: 15 nTPM
tongue: 15 nTPM
heart muscle: 14 nTPM

Single-cell type

choroid plexus epithelial cells: 49 nCPM
renal collecting duct intercalated cells: 31 nCPM
renal collecting duct principal cells: 28 nCPM
distal convoluted tubule cells: 26 nCPM
podocytes: 25 nCPM
renal connecting tubule cells: 25 nCPM

Immune cell

T-reg: 10 nTPM
memory CD4 T-cell: 9.2 nTPM
MAIT T-cell: 9.1 nTPM
memory CD8 T-cell: 8.7 nTPM
gdT-cell: 8.6 nTPM
naive CD4 T-cell: 8.4 nTPM

Brain region

choroid plexus: 45 nTPM
midbrain: 22 nTPM
white matter: 21 nTPM
medulla oblongata: 21 nTPM
pons: 20 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.01
gnomAD missense Z: 1.54
DepMap mean gene effect: -0.95
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

DNA-directed RNA polymerase III subunit Rpc5
DNA-directed RNA polymerase III subunit RPC5, C-terminal
RPC5 protein
DNA-directed RNA polymerase III subunit RPC5 C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLR3E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR3E as an antibody target. Whether an autoantibody or antibody against POLR3E could matter depends on whether native POLR3E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR3E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR3E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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