Seroatlas · Human Serome Atlas

POLR1G

DNA-directed RNA polymerase I subunit RPA34

Also known as: A34.5, ASE-1, CAST, CD3EAP, PAF49, RPA34, RPA34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15446
Gene: POLR1G
Ensembl: ENSG00000117877
Chromosome: 19
Canonical length: 510 aa
Protein class: Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Mitochondria

OverviewNCBI Gene

Enables RNA binding activity. Involved in transcription initiation at RNA polymerase I promoter. Located in cytosol; mitochondrion; and nuclear lumen. Part of RNA polymerase I complex. Implicated in multiple myeloma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>O15446|POLR1G
     1  MEEPQAGDAA RFSCPPNFTA KPPASESPRF SLEALTGPDT ELWLIQAPAD FAPECFNGRH
    61  VPLSGSQIVK GKLAGKRHRY RVLSSCPQAG EATLLAPSTE AGGGLTCASA PQGTLRILEG
   121  PQQSLSGSPL QPIPASPPPQ IPPGLRPRFC AFGGNPPVTG PRSALAPNLL TSGKKKKEMQ
   181  VTEAPVTQEA VNGHGALEVD MALGSPEMDV RKKKKKKNQQ LKEPEAAGPV GTEPTVETLE
   241  PLGVLFPSTT KKRKKPKGKE TFEPEDKTVK QEQINTEPLE DTVLSPTKKR KRQKGTEGME
   301  PEEGVTVESQ PQVKVEPLEE AIPLPPTKKR KKEKGQMAMM EPGTEAMEPV EPEMKPLESP
   361  GGTMAPQQPE GAKPQAQAAL AAPKKKTKKE KQQDATVEPE TEVVGPELPD DLEPQAAPTS
   421  TKKKKKKKER GHTVTEPIQP LEPELPGEGQ PEARATPGST KKRKKQSQES RMPETVPQEE
   481  MPGPPLNSES GEEAPTGRDK KRKQQQQQPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR1G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 6.2 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 6.2 nTPM
cerebellum: 5 nTPM
esophagus: 4.3 nTPM
tongue: 4.2 nTPM
skin: 4 nTPM
urinary bladder: 3.9 nTPM

Single-cell type

basal keratinocytes: 108 nCPM
suprabasal keratinocytes: 83 nCPM
gastric progenitor cells: 63 nCPM
esophageal basal cells: 48 nCPM
cardiomyocytes: 47 nCPM
differentiating spermatogonia: 40 nCPM

Immune cell

plasmacytoid DC: 15 nTPM
myeloid DC: 4.2 nTPM
intermediate monocyte: 3.4 nTPM
naive CD8 T-cell: 3.4 nTPM
MAIT T-cell: 3.1 nTPM
naive B-cell: 3 nTPM

Brain region

cerebellum: 20 nTPM
cerebral cortex: 20 nTPM
pons: 19 nTPM
white matter: 19 nTPM
medulla oblongata: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

chromosome
cytosol
fibrillar center
mitochondrion
nucleolus
nucleoplasm
RNA polymerase I complex
RNA polymerase I transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

DNA-directed RNA polymerase I, subunit RPA34
DNA-directed RNA polymerase I subunit RPA34.5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLR1G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR1G as an antibody target. Whether an autoantibody or antibody against POLR1G could matter depends on whether native POLR1G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR1G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR1G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...