Seroatlas · Human Serome Atlas

POLR3G

DNA-directed RNA polymerase III subunit RPC7

Also known as: C31, RPC32, RPC7, RPC7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15318
Gene: POLR3G
Ensembl: ENSG00000113356
Chromosome: 5
Canonical length: 223 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>O15318|POLR3G
     1  MAGNKGRGRA AYTFNIEAVG FSKGEKLPDV VLKPPPLFPD TDYKPVPLKT GEGEEYMLAL
    61  KQELRETMKR MPYFIETPEE RQDIERYSKR YMKVYKEEWI PDWRRLPREM MPRNKCKKAG
   121  PKPKKAKDAG KGTPLTNTED VLKKMEELEK RGDGEKSDEE NEEKEGSKEK SKEGDDDDDD
   181  DAAEQEEYDE EEQEEENDYI NSYFEDGDDF GADSDDNMDE ATY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLR3G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 7.2 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 7.2 nTPM
midbrain: 4.6 nTPM
epididymis: 4.4 nTPM
lymph node: 4.3 nTPM
testis: 4.2 nTPM
skin: 4.1 nTPM

Single-cell type

cardiomyocytes: 68 nCPM
cone photoreceptor cells: 60 nCPM
oocytes: 51 nCPM
oligodendrocytes: 47 nCPM
differentiating spermatogonia: 46 nCPM
other brain neurons: 46 nCPM

Immune cell

basophil: 3.3 nTPM
NK-cell: 2.9 nTPM
memory B-cell: 1.7 nTPM
gdT-cell: 1.5 nTPM
non-classical monocyte: 1.5 nTPM
naive CD8 T-cell: 1.2 nTPM

Brain region

pons: 24 nTPM
cerebellum: 22 nTPM
hypothalamus: 21 nTPM
white matter: 21 nTPM
cerebral cortex: 21 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLR3G in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLR3G as an antibody target. Whether an autoantibody or antibody against POLR3G could matter depends on whether native POLR3G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLR3G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLR3G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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