Seroatlas · Human Serome Atlas

NUP62

Nuclear pore glycoprotein p62

Also known as: DKFZp547L134, FLJ20822, FLJ43869, IBSN, MGC841, NUP62_HUMAN, p62, SNDI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P37198
Gene
NUP62
Ensembl
ENSG00000213024
Chromosome
19
Canonical length
522 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>P37198|NUP62
     1  MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF
    61  SLATQTPATQ TTGFTFGTAT LASGGTGFSL GIGASKLNLS NTAATPAMAN PSGFGLGSSN
   121  LTNAISSTVT SSQGTAPTGF VFGPSTTSVA PATTSGGFSF TGGSTAQPSG FNIGSAGNSA
   181  QPTAPATLPF TPATPAATTA GATQPAAPTP TATITSTGPS LFASIATAPT SSATTGLSLC
   241  TPVTTAGAPT AGTQGFSLKA PGAASGTSTT TSTAATATAT TTSSSSTTGF ALNLKPLAPA
   301  GIPSNTAAAV TAPPGPGAAA GAAASSAMTY AQLESLINKW SLELEDQERH FLQQATQVNA
   361  WDRTLIENGE KITSLHREVE KVKLDQKRLD QELDFILSQQ KELEDLLSPL EELVKEQSGT
   421  IYLQHADEER EKTYKLAENI DAQLKRMAQD LKDIIEHLNT SGAPADTSDP LQQICKILNA
   481  HMDSLQWIDQ NSALLQRKVE EVTKVCEGRR KEQERSFRIT FD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • testis: 45 nTPM
  • thymus: 38 nTPM
  • lymph node: 36 nTPM
  • appendix: 35 nTPM
  • tonsil: 34 nTPM
  • skeletal muscle: 31 nTPM

Single-cell type

  • late primary spermatocytes: 9.3 nCPM
  • late spermatids: 6.9 nCPM
  • early spermatids: 4.7 nCPM
  • oocytes: 4.6 nCPM
  • early primary spermatocytes: 3.7 nCPM
  • epididymal clear cells: 2 nCPM

Immune cell

  • intermediate monocyte: 35 nTPM
  • classical monocyte: 34 nTPM
  • myeloid DC: 34 nTPM
  • plasmacytoid DC: 30 nTPM
  • MAIT T-cell: 24 nTPM
  • total PBMC: 23 nTPM

Brain region

  • white matter: 33 nTPM
  • cerebellum: 32 nTPM
  • medulla oblongata: 31 nTPM
  • hypothalamus: 31 nTPM
  • pons: 30 nTPM
  • thalamus: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP62.

Disease | AllUniProt

Conditions NUP62 is implicated in, by any mechanism.

  • Infantile striatonigral degeneration (SNDI) MIM:271930

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 248 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Infantile bilateral striatal necrosis
  • Familial infantile bilateral striatal necrosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.95
gnomAD missense Z
0.01
DepMap mean gene effect
-0.61
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP62 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP62 as an antibody target. Whether an autoantibody or antibody against NUP62 could matter depends on whether native NUP62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUP62. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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