Seroatlas · Human Serome Atlas

CDYL2

Chromodomain Y-like protein 2

Also known as: CDYL2_HUMAN, FLJ38866

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8U2
Gene: CDYL2
Ensembl: ENSG00000166446
Chromosome: 16
Canonical length: 506 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>Q8N8U2|CDYL2
     1  MASGDLYEVE RIVDKRKNKK GKWEYLIRWK GYGSTEDTWE PEHHLLHCEE FIDEFNGLHM
    61  SKDKRIKSGK QSSTSKLLRD SRGPSVEKLS HRPSDPGKSK GTSHKRKRIN PPLAKPKKGY
   121  SGKPSSGGDR ATKTVSYRTT PSGLQIMPLK KSQNGMENGD AGSEKDERHF GNGSHQPGLD
   181  LNDHVGEQDM GECDVNHATL AENGLGSALT NGGLNLHSPV KRKLEAEKDY VFDKRLRYSV
   241  RQNESNCRFR DIVVRKEEGF THILLSSQTS DNNALTPEIM KEVRRALCNA ATDDSKLLLL
   301  SAVGSVFCSG LDYSYLIGRL SSDRRKESTR IAEAIRDFVK AFIQFKKPIV VAINGPALGL
   361  GASILPLCDI VWASEKAWFQ TPYATIRLTP AGCSSYTFPQ ILGVALANEM LFCGRKLTAQ
   421  EACSRGLVSQ VFWPTTFSQE VMLRVKEMAS CSAVVLEESK CLVRSFLKSV LEDVNEKECL
   481  MLKQLWSSSK GLDSLFSYLQ DKIYEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDYL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 13 nTPM
testis: 10 nTPM
placenta: 10 nTPM
prostate: 9.2 nTPM
seminal vesicle: 5.7 nTPM
bone marrow: 5.3 nTPM

Single-cell type

endometrial glandular cells: 409 nCPM
prostatic glandular cells: 363 nCPM
sertoli cells: 216 nCPM
renal collecting duct intercalated cells: 157 nCPM
neutrophil progenitors: 121 nCPM
brain excitatory neurons: 89 nCPM

Immune cell

non-classical monocyte: 4 nTPM
intermediate monocyte: 1 nTPM
eosinophil: 0.5 nTPM
basophil: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
myeloid DC: 0.2 nTPM

Brain region

midbrain: 65 nTPM
cerebellum: 40 nTPM
cerebral cortex: 33 nTPM
pons: 30 nTPM
hypothalamus: 29 nTPM
basal ganglia: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.02
gnomAD missense Z: -0.11
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of CDYL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDYL2 as an antibody target. Whether an autoantibody or antibody against CDYL2 could matter depends on whether native CDYL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDYL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDYL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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