Seroatlas · Human Serome Atlas

THOC5

THO complex subunit 5

Also known as: C22orf19, Fmip, fSAP79, KIAA0983, PK1.3, THOC5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13769
Gene: THOC5
Ensembl: ENSG00000100296
Chromosome: 22
Canonical length: 683 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable mRNA binding activity. Involved in mRNA export from nucleus and monocyte differentiation. Located in chromosome, telomeric region and nucleoplasm. Part of THO complex part of transcription export complex. Implicated in breast carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

683 residues, UniProt reviewed canonical sequence.

>Q13769|THOC5
     1  MSSESSKKRK PKVIRSDGAP AEGKRNRSDT EQEGKYYSEE AEVDLRDPGR DYELYKYTCQ
    61  ELQRLMAEIQ DLKSRGGKDV AIEIEERRIQ SCVHFMTLKK LNRLAHIRLK KGRDQTHEAK
   121  QKVDAYHLQL QNLLYEVMHL QKEITKCLEF KSKHEEIDLV SLEEFYKEAP PDISKAEVTM
   181  GDPHQQTLAR LDWELEQRKR LAEKYRECLS NKEKILKEIE VKKEYLSSLQ PRLNSIMQAS
   241  LPVQEYLFMP FDQAHKQYET ARHLPPPLYV LFVQATAYGQ ACDKTLSVAI EGSVDEAKAL
   301  FKPPEDSQDD ESDSDAEEEQ TTKRRRPTLG VQLDDKRKEM LKRHPLSVML DLKCKDDSVL
   361  HLTFYYLMNL NIMTVKAKVT TAMELITPIS AGDLLSPDSV LSCLYPGDHG KKTPNPANQY
   421  QFDKVGILTL SDYVLELGHP YLWVQKLGGL HFPKEQPQQT VIADHSLSAS HMETTMKLLK
   481  TRVQSRLALH KQFASLEHGI VPVTSDCQYL FPAKVVSRLV KWVTVAHEDY MELHFTKDIV
   541  DAGLAGDTNL YYMALIERGT AKLQAAVVLN PGYSSIPPVF QLCLNWKGEK TNSNDDNIRA
   601  MEGEVNVCYK ELCGPWPSHQ LLTNQLQRLC VLLDVYLETE SHDDSVEGPK EFPQEKMCLR
   661  LFRGPSRMKP FKYNHPQGFF SHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THOC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 41 nTPM
tongue: 38 nTPM
colon: 35 nTPM
blood vessel: 35 nTPM
endometrium: 31 nTPM
smooth muscle: 27 nTPM

Single-cell type

late spermatids: 215 nCPM
neutrophils: 77 nCPM
tuft cells: 69 nCPM
late primary spermatocytes: 56 nCPM
early spermatids: 43 nCPM
early primary spermatocytes: 42 nCPM

Immune cell

neutrophil: 43 nTPM
eosinophil: 40 nTPM
non-classical monocyte: 25 nTPM
intermediate monocyte: 20 nTPM
T-reg: 18 nTPM
myeloid DC: 17 nTPM

Brain region

cerebral cortex: 36 nTPM
pons: 36 nTPM
cerebellum: 34 nTPM
white matter: 34 nTPM
medulla oblongata: 33 nTPM
hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.05
gnomAD missense Z: 1.73
DepMap mean gene effect: -1.24
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mRNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

THO complex, subunit 5
Fms-interacting protein/Thoc5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THOC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THOC5 as an antibody target. Whether an autoantibody or antibody against THOC5 could matter depends on whether native THOC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THOC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THOC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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