Seroatlas · Human Serome Atlas

NUP42

Nucleoporin NUP42

Also known as: CG1, H_RG271G13.9, hCG1, NLP_1, NUP42_HUMAN, NUPL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15504
Gene
NUP42
Ensembl
ENSG00000136243
Chromosome
7
Canonical length
423 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear membrane,Cytosol

OverviewNCBI Gene

Enables nuclear export signal receptor activity. Involved in protein export from nucleus. Located in cytosol; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>O15504|NUP42
     1  MAICQFFLQG RCRFGDRCWN EHPGARGAGG GRQQPQQQPS GNNRRGWNTT SQRYSNVIQP
    61  SSFSKSTPWG GSRDQEKPYF SSFDSGASTN RKEGFGLSEN PFASLSPDEQ KDEKKLLEGI
   121  VKDMEVWESS GQWMFSVYSP VKKKPNISGF TDISPEELRL EYHNFLTSNN LQSYLNSVQR
   181  LINQWRNRVN ELKSLNISTK VALLSDVKDG VNQAAPAFGF GSSQAATFMS PGFPVNNSSS
   241  DNAQNFSFKT NSGFAAASSG SPAGFGSSPA FGAAASTSSG ISTSAPAFGF GKPEVTSAAS
   301  FSFKSPAASS FGSPGFSGLP ASLATGPVRA PVAPAFGGGS SVAGFGSPGS HSHTAFSKPS
   361  SDTFGNSSIS TSLSASSSII ATDNVLFTPR DKLTVEELEQ FQSKKFTLGK IPLKPPPLEL
   421  LNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 18 nTPM
  • lymph node: 17 nTPM
  • testis: 17 nTPM
  • heart muscle: 17 nTPM
  • tonsil: 17 nTPM
  • parathyroid gland: 16 nTPM

Single-cell type

  • early spermatids: 333 nCPM
  • oligodendrocyte progenitor cells: 216 nCPM
  • late primary spermatocytes: 202 nCPM
  • sertoli cells: 120 nCPM
  • microglia: 90 nCPM
  • adrenal cortex cells: 79 nCPM

Immune cell

  • memory B-cell: 18 nTPM
  • NK-cell: 16 nTPM
  • T-reg: 16 nTPM
  • myeloid DC: 15 nTPM
  • plasmacytoid DC: 13 nTPM
  • memory CD4 T-cell: 13 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • cerebral cortex: 13 nTPM
  • hippocampal formation: 11 nTPM
  • hypothalamus: 11 nTPM
  • amygdala: 11 nTPM
  • medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP42 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP42 as an antibody target. Whether an autoantibody or antibody against NUP42 could matter depends on whether native NUP42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUP42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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