Seroatlas · Human Serome Atlas

NXT1

NTF2-related export protein 1

Also known as: MTR2, NXT1_HUMAN, P15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKK6
Gene
NXT1
Ensembl
ENSG00000132661
Chromosome
20
Canonical length
140 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q9UKK6|NXT1
     1  MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN AVSGQESLSE
    61  FFEMLPSSEF QISVVDCQPV HDEATPSQTT VLVVICGSVK FEGNKQRDFN QNFILTAQAS
   121  PSNTVWKIAS DCFRFQDWAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 44 nTPM
  • blood vessel: 27 nTPM
  • adipose tissue: 26 nTPM
  • ovary: 24 nTPM
  • skin: 23 nTPM
  • fallopian tube: 21 nTPM

Single-cell type

  • oocytes: 207 nCPM
  • suprabasal keratinocytes: 153 nCPM
  • basal keratinocytes: 151 nCPM
  • esophageal basal cells: 112 nCPM
  • early primary spermatocytes: 102 nCPM
  • breast secretory cells: 99 nCPM

Immune cell

  • memory B-cell: 142 nTPM
  • naive B-cell: 132 nTPM
  • plasmacytoid DC: 114 nTPM
  • NK-cell: 108 nTPM
  • MAIT T-cell: 99 nTPM
  • naive CD4 T-cell: 98 nTPM

Brain region

  • pons: 8.5 nTPM
  • spinal cord: 8.4 nTPM
  • thalamus: 8.3 nTPM
  • hypothalamus: 8 nTPM
  • midbrain: 8 nTPM
  • medulla oblongata: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0.65
gnomAD missense Z
1.95
DepMap mean gene effect
-0.53
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NXT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXT1 as an antibody target. Whether an autoantibody or antibody against NXT1 could matter depends on whether native NXT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NXT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NXT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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