Seroatlas · Human Serome Atlas

UBXN1

UBX domain-containing protein 1

Also known as: 2B28, LOC51035, SAKS1, UBXD10, UBXN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q04323
Gene: UBXN1
Ensembl: ENSG00000162191
Chromosome: 11
Canonical length: 297 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Involved in negative regulation of protein metabolic process. Located in cytosol; endoplasmic reticulum; and nucleoplasm. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q04323|UBXN1
     1  MAELTALESL IEMGFPRGRA EKALALTGNQ GIEAAMDWLM EHEDDPDVDE PLETPLGHIL
    61  GREPTSSEQG GLEGSGSAAG EGKPALSEEE RQEQTKRMLE LVAQKQRERE EREEREALER
   121  ERQRRRQGQE LSAARQRLQE DEMRRAAEER RREKAEELAA RQRVREKIER DKAERAKKYG
   181  GSVGSQPPPV APEPGPVPSS PSQEPPTKRE YDQCRIQVRL PDGTSLTQTF RAREQLAAVR
   241  LYVELHRGEE LGGGQDPVQL LSGFPRRAFS EADMERPLQE LGLVPSAVLI VAKKCPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 272 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 272 nTPM
ovary: 142 nTPM
choroid plexus: 140 nTPM
blood vessel: 136 nTPM
adipose tissue: 132 nTPM
colon: 123 nTPM

Single-cell type

esophageal apical cells: 497 nCPM
syncytiotrophoblasts: 400 nCPM
late spermatids: 325 nCPM
decidual stromal cells: 317 nCPM
late primary spermatocytes: 312 nCPM
enterocytes: 297 nCPM

Immune cell

T-reg: 564 nTPM
total PBMC: 559 nTPM
memory B-cell: 537 nTPM
naive B-cell: 536 nTPM
naive CD4 T-cell: 496 nTPM
non-classical monocyte: 443 nTPM

Brain region

medulla oblongata: 70 nTPM
white matter: 64 nTPM
basal ganglia: 64 nTPM
thalamus: 60 nTPM
spinal cord: 60 nTPM
cerebellum: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.73
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN1 as an antibody target. Whether an autoantibody or antibody against UBXN1 could matter depends on whether native UBXN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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