Seroatlas · Human Serome Atlas

TRAFD1

TRAF-type zinc finger domain-containing protein 1

Also known as: FLN29, TRAD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14545
Gene
TRAFD1
Ensembl
ENSG00000135148
Chromosome
12
Canonical length
582 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]

Canonical amino-acid sequenceUniProt

582 residues, UniProt reviewed canonical sequence.

>O14545|TRAFD1
     1  MAEFLDDQET RLCDNCKKEI PVFNFTIHEI HCQRNIGMCP TCKEPFPKSD METHMAAEHC
    61  QVTCKCNKKL EKRLLKKHEE TECPLRLAVC QHCDLELSIL KLKEHEDYCG ARTELCGNCG
   121  RNVLVKDLKT HPEVCGREGE EKRNEVAIPP NAYDESWGQD GIWIASQLLR QIEALDPPMR
   181  LPRRPLRAFE SDVFHNRTTN QRNITAQVSI QNNLFEEQER QERNRGQQPP KEGGEESANL
   241  DFMLALSLQN EGQASSVAEQ DFWRAVCEAD QSHGGPRSLS DIKGAADEIM LPCEFCEELY
   301  PEELLIDHQT SCNPSRALPS LNTGSSSPRG VEEPDVIFQN FLQQAASNQL DSLMGLSNSH
   361  PVEESIIIPC EFCGVQLEEE VLFHHQDQCD QRPATATNHV TEGIPRLDSQ PQETSPELPR
   421  RRVRHQGDLS SGYLDDTKQE TANGPTSCLP PSRPINNMTA TYNQLSRSTS GPRPGCQPSS
   481  PCVPKLSNSD SQDIQGRNRD SQNGAIAPGH VSVIRPPQNL YPENIVPSFS PGPSGRYGAS
   541  GRSEGGRNSR VTPAAANYRS RTAKAKPSKQ QGAGDAEEEE EE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAFD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • colon: 39 nTPM
  • tonsil: 38 nTPM
  • lymph node: 35 nTPM
  • skin: 35 nTPM
  • choroid plexus: 32 nTPM
  • esophagus: 31 nTPM

Single-cell type

  • early primary spermatocytes: 116 nCPM
  • choroid plexus epithelial cells: 62 nCPM
  • retinal pigment epithelial cells: 55 nCPM
  • urothelial cells: 49 nCPM
  • neutrophils: 47 nCPM
  • prostatic club cells: 42 nCPM

Immune cell

  • basophil: 324 nTPM
  • eosinophil: 227 nTPM
  • neutrophil: 189 nTPM
  • total PBMC: 101 nTPM
  • classical monocyte: 96 nTPM
  • non-classical monocyte: 94 nTPM

Brain region

  • white matter: 46 nTPM
  • choroid plexus: 36 nTPM
  • medulla oblongata: 32 nTPM
  • cerebellum: 29 nTPM
  • basal ganglia: 29 nTPM
  • pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.62
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAFD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAFD1 as an antibody target. Whether an autoantibody or antibody against TRAFD1 could matter depends on whether native TRAFD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAFD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAFD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAFD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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