Seroatlas · Human Serome Atlas

TTLL12

Tubulin--tyrosine ligase-like protein 12

Also known as: KIAA0153, TTL12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14166
Gene: TTLL12
Ensembl: ENSG00000100304
Chromosome: 22
Canonical length: 644 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables histone H4K20me3 reader activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

644 residues, UniProt reviewed canonical sequence.

>Q14166|TTLL12
     1  MEAERGPERR PAERSSPGQT PEEGAQALAE FAALHGPALR ASGVPERYWG RLLHKLEHEV
    61  FDAGEVFGIM QVEEVEEEED EAAREVRKQQ PNPGNELCYK VIVTRESGLQ AAHPNSIFLI
   121  DHAWTCRVEH ARQQLQQVPG LLHRMANLMG IEFHGELPST EAVALVLEEM WKFNQTYQLA
   181  HGTAEEKMPV WYIMDEFGSR IQHADVPSFA TAPFFYMPQQ VAYTLLWPLR DLDTGEEVTR
   241  DFAYGETDPL IRKCMLLPWA PTDMLDLSSC TPEPPAEHYQ AILEENKEKL PLDINPVVHP
   301  HGHIFKVYTD VQQVASSLTH PRFTLTQSEA DADILFNFSH FKDYRKLSQE RPGVLLNQFP
   361  CENLLTVKDC LASIARRAGG PEGPPWLPRT FNLRTELPQF VSYFQQRERW GEDNHWICKP
   421  WNLARSLDTH VTKSLHSIIR HRESTPKVVS KYIESPVLFL REDVGKVKFD IRYIVLLRSV
   481  RPLRLFVYDV FWLRFSNRAF ALNDLDDYEK HFTVMNYDPD VVLKQVHCEE FIPEFEKQYP
   541  EFPWTDVQAE IFRAFTELFQ VACAKPPPLG LCDYPSSRAM YAVDLMLKWD NGPDGRRVMQ
   601  PQILEVNFNP DCERACRYHP TFFNDVFSTL FLDQPGGCHV TCLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTLL12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

esophagus: 99 nTPM
skin: 35 nTPM
vagina: 35 nTPM
colon: 33 nTPM
stomach: 32 nTPM
cervix: 27 nTPM

Single-cell type

esophageal apical cells: 294 nCPM
esophageal suprabasal cells: 136 nCPM
esophageal basal cells: 97 nCPM
colonocytes: 61 nCPM
erythrocyte progenitors: 51 nCPM
suprabasal keratinocytes: 47 nCPM

Immune cell

gdT-cell: 2.6 nTPM
MAIT T-cell: 2.5 nTPM
memory CD4 T-cell: 2.5 nTPM
naive CD4 T-cell: 2.4 nTPM
classical monocyte: 2.3 nTPM
NK-cell: 2.3 nTPM

Brain region

pons: 45 nTPM
cerebral cortex: 42 nTPM
medulla oblongata: 36 nTPM
cerebellum: 32 nTPM
hypothalamus: 32 nTPM
hippocampal formation: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: -0.81
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tubulin-tyrosine ligase/Tubulin polyglutamylase
Tubulin-tyrosine ligase family
Tubulin--tyrosine ligase-like protein 12
Tubulin--tyrosine ligase-like protein 12, SET-like domain
Tubulin tyrosine ligase SET-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTLL12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTLL12 as an antibody target. Whether an autoantibody or antibody against TTLL12 could matter depends on whether native TTLL12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTLL12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTLL12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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