Seroatlas · Human Serome Atlas

N4BP3

NEDD4-binding protein 3

Also known as: LZTS4, N4BP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15049
Gene: N4BP3
Ensembl: ENSG00000145911
Chromosome: 5
Canonical length: 544 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

Acts upstream of with a positive effect on innate immune response. Predicted to be located in axon and dendrite. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>O15049|N4BP3
     1  MATAPGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL GQREFLSYLH
    61  LPKKDSKSTK NTKRAPRNEP ADYATLYYRE HSRAGDFSKT SLPERGRFDK CRIRPSVFKP
   121  TAGNGKGFLS MQSLASHKGQ KLWRSNGSLH TLACHPPLSP GPRASQARAQ LLHALSLDEG
   181  GPEPEPSLSD SSSGGSFGRS PGTGPSPFSS SLGHLNHLGG SLDRASQGPK EAGPPAVLSC
   241  LPEPPPPYEF SCSSAEEMGA VLPETCEELK RGLGDEDGSN PFTQVLEERQ RLWLAELKRL
   301  YVERLHEVTQ KAERSERNLQ LQLFMAQQEQ RRLRKELRAQ QGLAPEPRAP GTLPEADPSA
   361  RPEEEARWEV CQKTAEISLL KQQLREAQAE LAQKLAEIFS LKTQLRGSRA QAQAQDAELV
   421  RLREAVRSLQ EQAPREEAPG SCETDDCKSR GLLGEAGGSE ARDSAEQLRA ELLQERLRGQ
   481  EQALRFEQER RTWQEEKERV LRYQREIQGG YMDMYRRNQA LEQELRALRE PPTPWSPRLE
   541  SSKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against N4BP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

esophagus: 15 nTPM
placenta: 7.8 nTPM
skin: 7.6 nTPM
salivary gland: 6.4 nTPM
cerebellum: 5 nTPM
retina: 4.3 nTPM

Single-cell type

esophageal apical cells: 256 nCPM
extravillous trophoblasts: 203 nCPM
esophageal suprabasal cells: 66 nCPM
epididymal clear cells: 33 nCPM
syncytiotrophoblasts: 29 nCPM
retinal bipolar cells: 27 nCPM

Immune cell

plasmacytoid DC: 2.1 nTPM
memory B-cell: 1.7 nTPM
naive B-cell: 1.6 nTPM
naive CD8 T-cell: 1.2 nTPM
naive CD4 T-cell: 0.4 nTPM
gdT-cell: 0.2 nTPM

Brain region

thalamus: 14 nTPM
cerebral cortex: 12 nTPM
cerebellum: 11 nTPM
pons: 10 nTPM
hypothalamus: 9 nTPM
white matter: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Fez1
NEDD4-binding protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of N4BP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads N4BP3 as an antibody target. Whether an autoantibody or antibody against N4BP3 could matter depends on whether native N4BP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

N4BP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label N4BP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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