Seroatlas · Human Serome Atlas

NDFIP1

NEDD4 family-interacting protein 1

Also known as: MGC10924, N4WBP5, NFIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BT67
Gene: NDFIP1
Ensembl: ENSG00000131507
Chromosome: 5
Canonical length: 221 aa
Protein class: Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q9BT67|NDFIP1
     1  MALALAALAA VEPACGSRYQ QLQNEEESGE PEQAAGDAPP PYSSISAESA AYFDYKDESG
    61  FPKPPSYNVA TTLPSYDEAE RTKAEATIPL VPGRDEDFVG RDDFDDADQL RIGNDGIFML
   121  TFFMAFLFNW IGFFLSFCLT TSAAGRYGAI SGFGLSLIKW ILIVRFSTYF PGYFDGQYWL
   181  WWVFLVLGFL LFLRGFINYA KVRKMPETFS NLPRTRVLFI Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDFIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 152 nTPM

Expression across tissuesHPA

Tissue

retina: 152 nTPM
cerebral cortex: 151 nTPM
parathyroid gland: 144 nTPM
epididymis: 128 nTPM
liver: 112 nTPM
hypothalamus: 106 nTPM

Single-cell type

epididymal principal cells: 560 nCPM
rod photoreceptor cells: 535 nCPM
extravillous trophoblasts: 430 nCPM
breast lactating cells: 405 nCPM
retinal horizontal cells: 403 nCPM
esophageal apical cells: 378 nCPM

Immune cell

naive CD4 T-cell: 81 nTPM
basophil: 71 nTPM
naive CD8 T-cell: 64 nTPM
total PBMC: 62 nTPM
T-reg: 51 nTPM
memory CD4 T-cell: 41 nTPM

Brain region

hypothalamus: 162 nTPM
cerebral cortex: 153 nTPM
basal ganglia: 151 nTPM
thalamus: 149 nTPM
hippocampal formation: 123 nTPM
pons: 121 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.98
gnomAD missense Z: 1.5
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

WW domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDFIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDFIP1 as an antibody target. Whether an autoantibody or antibody against NDFIP1 could matter depends on whether native NDFIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDFIP1 is annotated as secreted, so native NDFIP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NDFIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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