Seroatlas · Human Serome Atlas

MAPK1

Mitogen-activated protein kinase 1

Also known as: ERK, ERK2, MAPK2, MK01_HUMAN, p41mapk, PRKM1, PRKM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28482
Gene
MAPK1
Ensembl
ENSG00000100030
Chromosome
22
Canonical length
360 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Microtubules,Primary cilium,Primary cilium tip,Basal body

OverviewNCBI Gene

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>P28482|MAPK1
     1  MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE
    61  HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH
   121  LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH
   181  TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI
   241  LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK
   301  RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
96 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 96 nTPM
  • cerebral cortex: 86 nTPM
  • amygdala: 62 nTPM
  • hippocampal formation: 58 nTPM
  • cerebellum: 49 nTPM
  • parathyroid gland: 49 nTPM

Single-cell type

  • neutrophils: 1,045 nCPM
  • neutrophil progenitors: 707 nCPM
  • mast cells: 608 nCPM
  • nk-cells: 380 nCPM
  • monocytes: 262 nCPM
  • monocyte progenitors: 230 nCPM

Immune cell

  • neutrophil: 17 nTPM
  • gdT-cell: 16 nTPM
  • NK-cell: 9.3 nTPM
  • eosinophil: 7.3 nTPM
  • non-classical monocyte: 6.9 nTPM
  • naive CD8 T-cell: 6.1 nTPM

Brain region

  • cerebral cortex: 218 nTPM
  • basal ganglia: 205 nTPM
  • hippocampal formation: 197 nTPM
  • amygdala: 163 nTPM
  • hypothalamus: 155 nTPM
  • midbrain: 128 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAPK1.

Disease | AllUniProt

Conditions MAPK1 is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on MAPK1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
3.61
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPK1 as an antibody target. Whether an autoantibody or antibody against MAPK1 could matter depends on whether native MAPK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPK1 is annotated at the cell surface, where native MAPK1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAPK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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