STYX
Serine/threonine/tyrosine-interacting protein
Also known as: STYX_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WUJ0
- Gene
- STYX
- Ensembl
- ENSG00000198252
- Chromosome
- 14
- Canonical length
- 223 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
Canonical amino-acid sequenceUniProt
223 residues, UniProt reviewed canonical sequence.
>Q8WUJ0|STYX
1 MEDVKLEFPS LPQCKEDAEE WTYPMRREMQ EILPGLFLGP YSSAMKSKLP VLQKHGITHI
61 ICIRQNIEAN FIKPNFQQLF RYLVLDIADN PVENIIRFFP MTKEFIDGSL QMGGKVLVHG
121 NAGISRSAAF VIAYIMETFG MKYRDAFAYV QERRFCINPN AGFVHQLQEY EAIYLAKLTI
181 QMMSPLQIER SLSVHSGTTG SLKRTHEEED DFGTMQVATA QNGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against STYX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- liver: 25 nTPM
- lymph node: 13 nTPM
- tongue: 12 nTPM
- tonsil: 12 nTPM
- skeletal muscle: 11 nTPM
- testis: 10 nTPM
Single-cell type
- late primary spermatocytes: 148 nCPM
- late spermatids: 133 nCPM
- early spermatids: 98 nCPM
- hepatocytes: 75 nCPM
- early primary spermatocytes: 58 nCPM
- extravillous trophoblasts: 48 nCPM
Immune cell
- T-reg: 11 nTPM
- naive CD4 T-cell: 11 nTPM
- memory CD4 T-cell: 9.2 nTPM
- naive CD8 T-cell: 8.2 nTPM
- basophil: 7.7 nTPM
- memory CD8 T-cell: 7.6 nTPM
Brain region
- white matter: 12 nTPM
- medulla oblongata: 11 nTPM
- midbrain: 11 nTPM
- basal ganglia: 10 nTPM
- cerebellum: 10 nTPM
- pons: 10 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.51
- gnomAD pLI
- 0.38
- gnomAD missense Z
- 1.47
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of protein binding
- negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
- regulation of ERK1 and ERK2 cascade
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of STYX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads STYX as an antibody target. Whether an autoantibody or antibody against STYX could matter depends on whether native STYX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
STYX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label STYX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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