Seroatlas · Human Serome Atlas

DUSP1

Dual specificity protein phosphatase 1

Also known as: CL100, DUS1_HUMAN, HVH1, MKP-1, PTPN10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28562
Gene
DUSP1
Ensembl
ENSG00000120129
Chromosome
5
Canonical length
367 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>P28562|DUSP1
     1  MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM
    61  GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARAAQVFF
   121  LKGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILPF
   181  LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA
   241  IDFIDSIKNA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS
   301  FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQSP
   361  ITTSPSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
1,059 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 1,059 nTPM
  • skin: 1,001 nTPM
  • adipose tissue: 875 nTPM
  • urinary bladder: 725 nTPM
  • fallopian tube: 680 nTPM
  • lung: 678 nTPM

Single-cell type

  • neutrophils: 6,470 nCPM
  • esophageal apical cells: 3,857 nCPM
  • smooth muscle cells: 2,355 nCPM
  • monocytes: 2,272 nCPM
  • cdc: 1,732 nCPM
  • decidual stromal cells: 1,706 nCPM

Immune cell

  • neutrophil: 7,453 nTPM
  • eosinophil: 1,645 nTPM
  • basophil: 932 nTPM
  • non-classical monocyte: 795 nTPM
  • intermediate monocyte: 589 nTPM
  • classical monocyte: 585 nTPM

Brain region

  • choroid plexus: 195 nTPM
  • medulla oblongata: 190 nTPM
  • cerebellum: 188 nTPM
  • spinal cord: 174 nTPM
  • white matter: 166 nTPM
  • thalamus: 158 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0.01
gnomAD missense Z
1.72
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DUSP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP1 as an antibody target. Whether an autoantibody or antibody against DUSP1 could matter depends on whether native DUSP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DUSP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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