Seroatlas · Human Serome Atlas

MAP2K1

Dual specificity mitogen-activated protein kinase kinase 1

Also known as: MAPKK1, MEK1, MP2K1_HUMAN, PRKMK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02750
Gene
MAP2K1
Ensembl
ENSG00000169032
Chromosome
15
Canonical length
393 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Plasma membrane,Basal body,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q02750|MAP2K1
     1  MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV
    61  GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE
   121  CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL
   181  REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY
   241  SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY
   301  GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF
   361  IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP2K1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 76 nTPM
  • skeletal muscle: 60 nTPM
  • tonsil: 44 nTPM
  • adipose tissue: 44 nTPM
  • basal ganglia: 43 nTPM
  • cerebellum: 43 nTPM

Single-cell type

  • monocytes: 1,195 nCPM
  • neutrophils: 799 nCPM
  • esophageal apical cells: 779 nCPM
  • cdc: 568 nCPM
  • neutrophil progenitors: 560 nCPM
  • monocyte progenitors: 361 nCPM

Immune cell

  • plasmacytoid DC: 13 nTPM
  • myeloid DC: 7.5 nTPM
  • classical monocyte: 7.2 nTPM
  • intermediate monocyte: 7.1 nTPM
  • NK-cell: 7.1 nTPM
  • non-classical monocyte: 7.1 nTPM

Brain region

  • cerebral cortex: 148 nTPM
  • hippocampal formation: 127 nTPM
  • basal ganglia: 92 nTPM
  • white matter: 85 nTPM
  • hypothalamus: 80 nTPM
  • pons: 70 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAP2K1.

Disease | AllUniProt

Conditions MAP2K1 is implicated in, by any mechanism.

Disease | GeneticClinVar

57 pathogenic / likely-pathogenic of 737 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.9
gnomAD missense Z
3.11
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP2K1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP2K1 as an antibody target. Whether an autoantibody or antibody against MAP2K1 could matter depends on whether native MAP2K1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP2K1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP2K1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAP2K1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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