PEA15

Protein identityUniProt · HPA

UniProt accession

Q15121

Gene

PEA15

Ensembl

ENSG00000162734

Chromosome

1

Canonical length

130 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>Q15121|PEA15
     1  MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL
    61  SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI
   121  IKLAPPPKKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEA15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

1,946 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.58

gnomAD pLI

0.79

gnomAD missense Z

2.24

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• MAPK cascade
• negative regulation of D-glucose import
• negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
• positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular components

• cytosol
• microtubule associated complex
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Death effector domain
• Death-like domain superfamily
• Death effector domain
• Astrocytic phosphoprotein PEA-15, death effector domain

KeywordsUniProt

• Apoptosis
• Cytoplasm
• Phosphoprotein
• Sugar transport
• Transport

InteractionsUniProt · HPA

Protein binding partners of PEA15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CASP8
• FADD
• MAPK3
• MAPK1