Seroatlas · Human Serome Atlas

CDK2AP2

Cyclin-dependent kinase 2-associated protein 2

Also known as: CDKA2_HUMAN, DOC-1R, p14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75956
Gene: CDK2AP2
Ensembl: ENSG00000167797
Chromosome: 11
Canonical length: 126 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>O75956|CDK2AP2
     1  MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND FGPPSMGYVQ
    61  AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME RLKRGIIHAR ALVRECLAET
   121  ERNART

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK2AP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 173 nTPM

Expression across tissuesHPA

Tissue

liver: 173 nTPM
kidney: 143 nTPM
heart muscle: 138 nTPM
blood vessel: 116 nTPM
thyroid gland: 110 nTPM
adrenal gland: 109 nTPM

Single-cell type

epididymal principal cells: 904 nCPM
megakaryocytes: 278 nCPM
epididymal efferent duct absorptive cells: 256 nCPM
extravillous trophoblasts: 242 nCPM
syncytiotrophoblasts: 227 nCPM
esophageal apical cells: 214 nCPM

Immune cell

plasmacytoid DC: 796 nTPM
gdT-cell: 299 nTPM
NK-cell: 293 nTPM
T-reg: 292 nTPM
basophil: 286 nTPM
memory CD8 T-cell: 268 nTPM

Brain region

medulla oblongata: 80 nTPM
white matter: 64 nTPM
spinal cord: 64 nTPM
cerebellum: 61 nTPM
pons: 60 nTPM
midbrain: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.79
gnomAD missense Z: 1.43
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK2AP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK2AP2 as an antibody target. Whether an autoantibody or antibody against CDK2AP2 could matter depends on whether native CDK2AP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK2AP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK2AP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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