CAVIN4

Protein identityUniProt · HPA

UniProt accession

Q5BKX8

Gene

CAVIN4

Ensembl

ENSG00000170681

Chromosome

9

Canonical length

364 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Plasma membrane

OverviewNCBI Gene

This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q5BKX8|CAVIN4
     1  MEHNGSASNA DKIHQNRLSS VTEDEDQDAA LTIVTVLDKV ASIVDSVQAS QKRIEERHRE
    61  MENAIKSVQI DLLKLSQSHS NTGHIINKLF EKTRKVSAHI KDVKARVEKQ QIHVKKVEVK
   121  QEEIMKKNKF RVVIFQEKFR CPTSLSVVKD RNLTENQEED DDDIFDPPVD LSSDEEYYVE
   181  ESRSARLRKS GKEHIDNIKK AFSKENMQKT RQNLDKKVNR IRTRIVTPER RERLRQSGER
   241  LRQSGERLRQ SGERFKKSIS NAAPSKEAFK MRSLRKGKDR TVAEGEECAR EMGVDIIARS
   301  ESLGPISELY SDELSEPEHE AARPVYPPHE GREIPTPEPL KVTFKSQVKV EDDESLLLDL
   361  KHSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAVIN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

258 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for CAVIN4 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.27

gnomAD pLI

0

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• muscle organ development
• positive regulation of transcription by RNA polymerase II
• regulation of gene expression

Cellular components

• caveola
• cytoplasm
• cytosol
• plasma membrane
• sarcolemma
• sarcoplasm
• Z disc

Protein domainsUniProt · Pfam · InterPro

• Cavin family
• PTRF/SDPR family

KeywordsUniProt

• Activator
• Cell membrane
• Coiled coil
• Cytoplasm
• Developmental protein
• Differentiation
• Membrane
• Myogenesis
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of CAVIN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ADRA1A
• ADRA1B
• CAV3
• CAVIN1
• CAVIN2
• MAPK1
• MAPK3