RPS6KA2

Protein identityUniProt · HPA

UniProt accession

Q15349

Gene

RPS6KA2

Ensembl

ENSG00000071242

Chromosome

6

Canonical length

733 aa

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

733 residues, UniProt reviewed canonical sequence.

>Q15349|RPS6KA2
     1  MDLSMKKFAV RRFFSVYLRR KSRSKSSSLS RLEEEGVVKE IDISHHVKEG FEKADPSQFE
    61  LLKVLGQGSY GKVFLVRKVK GSDAGQLYAM KVLKKATLKV RDRVRSKMER DILAEVNHPF
   121  IVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL ALDHLHSLGI
   181  IYRDLKPENI LLDEEGHIKI TDFGLSKEAI DHDKRAYSFC GTIEYMAPEV VNRRGHTQSA
   241  DWWSFGVLMF EMLTGSLPFQ GKDRKETMAL ILKAKLGMPQ FLSGEAQSLL RALFKRNPCN
   301  RLGAGIDGVE EIKRHPFFVT IDWNTLYRKE IKPPFKPAVG RPEDTFHFDP EFTARTPTDS
   361  PGVPPSANAH HLFRGFSFVA SSLIQEPSQQ DLHKVPVHPI VQQLHGNNIH FTDGYEIKED
   421  IGVGSYSVCK RCVHKATDTE YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK
   481  FVYLVMELMR GGELLDRILR QRYFSEREAS DVLCTITKTM DYLHSQGVVH RDLKPSNILY
   541  RDESGSPESI RVCDFGFAKQ LRAGNGLLMT PCYTANFVAP EVLKRQGYDA ACDIWSLGIL
   601  LYTMLAGFTP FANGPDDTPE EILARIGSGK YALSGGNWDS ISDAAKDVVS KMLHVDPHQR
   661  LTAMQVLKHP WVVNREYLSP NQLSRQDVHL VKGAMAATYF ALNRTPQAPR LEPVLSSNLA
   721  QRRGMKRLTS TRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS6KA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

72 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.01

gnomAD missense Z

2.58

DepMap mean gene effect

-0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• brain renin-angiotensin system
• cardiac muscle cell apoptotic process
• cellular response to carbohydrate stimulus
• chemical synaptic transmission
• heart contraction
• heart development
• intracellular signal transduction
• negative regulation of cell cycle
• negative regulation of cell population proliferation
• negative regulation of meiotic nuclear division
• oocyte maturation
• positive regulation of apoptotic process
• positive regulation of gene expression
• regulation of protein processing
• signal transduction
• TORC1 signaling

Molecular functions

• ATP binding
• magnesium ion binding
• protein serine kinase activity
• protein serine/threonine kinase activity
• protein serine/threonine/tyrosine kinase activity
• ribosomal protein S6 kinase activity

Cellular components

• cytoplasm
• cytosol
• meiotic spindle
• nucleoplasm
• nucleus
• synapse

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• AGC-kinase, C-terminal
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Ribosomal protein S6 kinase II
• Protein kinase, ATP binding site
• Protein kinase, C-terminal
• Ribosomal S6 kinase, N-terminal catalytic domain
• Protein kinase domain
• Protein kinase C terminal domain
• RSK3, C-terminal catalytic domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Repeat
• Serine/threonine-protein kinase
• Transferase
• Tumor suppressor

InteractionsUniProt · HPA

Protein binding partners of RPS6KA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FBXO5
• CSNK2B
• MAPK1