Seroatlas · Human Serome Atlas

TNIP1

TNFAIP3-interacting protein 1

Also known as: ABIN-1, KIAA0113, NAF1, TNIP1_HUMAN, VAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15025
Gene: TNIP1
Ensembl: ENSG00000145901
Chromosome: 5
Canonical length: 636 aa
Protein class: Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>Q15025|TNIP1
     1  MEGRGPYRIY DPGGSVPSGE ASAAFERLVK ENSRLKEKMQ GIKMLGELLE ESQMEATRLR
    61  QKAEELVKDN ELLPPPSPSL GSFDPLAELT GKDSNVTASP TAPACPSDKP APVQKPPSSG
   121  TSSEFEVVTP EEQNSPESSS HANAMALGPL PREDGNLMLH LQRLETTLSV CAEEPDHGQL
   181  FTHLGRMALE FNRLASKVHK NEQRTSILQT LCEQLRKENE ALKAKLDKGL EQRDQAAERL
   241  REENLELKKL LMSNGNKEGA SGRPGSPKME GTGKKAVAGQ QQASVTAGKV PEVVALGAAE
   301  KKVKMLEQQR SELLEVNKQW DQHFRSMKQQ YEQKITELRQ KLADLQKQVT DLEAEREQKQ
   361  RDFDRKLLLA KSKIEMEETD KEQLTAEAKE LRQKVKYLQD QLSPLTRQRE YQEKEIQRLN
   421  KALEEALSIQ TPPSSPPTAF GSPEGAGALL RKQELVTQNE LLKQQVKIFE EDFQRERSDR
   481  ERMNEEKEEL KKQVEKLQAQ VTLSNAQLKA FKDEEKAREA LRQQKRKAKA SGERYHVEPH
   541  PEHLCGAYPY AYPPMPAMVP HHGFEDWSQI RYPPPPMAME HPPPLPNSRL FHLPEYTWRL
   601  PCGGVRNPNQ SSQVMDPPTA RPTEPESPKN DREGPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 198 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 198 nTPM
tongue: 122 nTPM
bone marrow: 121 nTPM
adipose tissue: 113 nTPM
liver: 102 nTPM
spleen: 95 nTPM

Single-cell type

neutrophils: 716 nCPM
esophageal apical cells: 666 nCPM
enterocytes: 330 nCPM
monocytes: 232 nCPM
epididymal efferent duct absorptive cells: 224 nCPM
colonocytes: 215 nCPM

Immune cell

neutrophil: 42 nTPM
eosinophil: 36 nTPM
T-reg: 21 nTPM
basophil: 18 nTPM
naive B-cell: 17 nTPM
MAIT T-cell: 14 nTPM

Brain region

cerebral cortex: 56 nTPM
medulla oblongata: 56 nTPM
pons: 51 nTPM
spinal cord: 50 nTPM
midbrain: 50 nTPM
thalamus: 49 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNIP1.

Disease | ImmuneIEDB

Conditions an epitope on TNIP1 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.48
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNIP1 as an antibody target. Whether an autoantibody or antibody against TNIP1 could matter depends on whether native TNIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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