Seroatlas · Human Serome Atlas

GIT1

ARF GTPase-activating protein GIT1

Also known as: GIT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2X7
Gene
GIT1
Ensembl
ENSG00000108262
Chromosome
17
Canonical length
761 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Focal adhesion sites,Mitochondria,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables gamma-tubulin binding activity. Involved in positive regulation of microtubule nucleation and regulation of cytokinesis. Located in several cellular components, including focal adhesion; microtubule cytoskeleton; and mitochondrion. Implicated in attention deficit hyperactivity disorder. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

761 residues, UniProt reviewed canonical sequence.

>Q9Y2X7|GIT1
     1  MSRKGPRAEV CADCSAPDPG WASISRGVLV CDECCSVHRS LGRHISIVKH LRHSAWPPTL
    61  LQMVHTLASN GANSIWEHSL LDPAQVQSGR RKANPQDKVH PIKSEFIRAK YQMLAFVHKL
   121  PCRDDDGVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGTTP LHVAAKAGQT
   181  LQAELLVVYG ADPGSPDVNG RTPIDYARQA GHHELAERLV ECQYELTDRL AFYLCGRKPD
   241  HKNGHYIIPQ MADSLDLSEL AKAAKKKLQA LSNRLFEELA MDVYDEVDRR ENDAVWLATQ
   301  NHSTLVTERS AVPFLPVNPE YSATRNQGRQ KLARFNAREF ATLIIDILSE AKRRQQGKSL
   361  SSPTDNLELS LRSQSDLDDQ HDYDSVASDE DTDQEPLRST GATRSNRARS MDSSDLSDGA
   421  VTLQEYLELK KALATSEAKV QQLMKVNSSL SDELRRLQRE IHKLQAENLQ LRQPPGPVPT
   481  PPLPSERAEH TPMAPGGSTH RRDRQAFSMY EPGSALKPFG GPPGDELTTR LQPFHSTELE
   541  DDAIYSVHVP AGLYRIRKGV SASAVPFTPS SPLLSCSQEG SRHTSKLSRH GSGADSDYEN
   601  TQSGDPLLGL EGKRFLELGK EEDFHPELES LDGDLDPGLP STEDVILKTE QVTKNIQELL
   661  RAAQEFKHDS FVPCSEKIHL AVTEMASLFP KRPALEPVRS SLRLLNASAY RLQSECRKTV
   721  PPEPGAPVDF QLLTQQVIQC AYDIAKAAKQ LVTITTREKK Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
128 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 128 nTPM
  • cerebral cortex: 109 nTPM
  • basal ganglia: 95 nTPM
  • amygdala: 94 nTPM
  • testis: 83 nTPM
  • cerebellum: 53 nTPM

Single-cell type

  • late spermatids: 134 nCPM
  • late primary spermatocytes: 99 nCPM
  • early spermatids: 98 nCPM
  • vascular endothelial cells: 51 nCPM
  • lymphatic endothelial cells: 50 nCPM
  • schwann cells: 48 nCPM

Immune cell

  • intermediate monocyte: 2.5 nTPM
  • NK-cell: 2.4 nTPM
  • myeloid DC: 2.2 nTPM
  • memory CD8 T-cell: 2.1 nTPM
  • gdT-cell: 1.9 nTPM
  • memory CD4 T-cell: 1.9 nTPM

Brain region

  • cerebral cortex: 267 nTPM
  • hippocampal formation: 225 nTPM
  • basal ganglia: 199 nTPM
  • amygdala: 179 nTPM
  • white matter: 139 nTPM
  • thalamus: 121 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GIT1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 127 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • GIT1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
3.06
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GIT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIT1 as an antibody target. Whether an autoantibody or antibody against GIT1 could matter depends on whether native GIT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIT1 is annotated at the cell surface, where native GIT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GIT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GIT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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