PTPN7

Protein identityUniProt · HPA

UniProt accession

P35236

Gene

PTPN7

Ensembl

ENSG00000143851

Chromosome

1

Canonical length

360 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Microtubules,Mitotic spindle,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>P35236|PTPN7
     1  MVQAHGGRSR AQPLTLSLGA AMTQPPPEKT PAKKHVRLQE RRGSNVALML DVRSLGAVEP
    61  ICSVNTPREV TLHFLRTAGH PLTRWALQRQ PPSPKQLEEE FLKIPSNFVS PEDLDIPGHA
   121  SKDRYKTILP NPQSRVCLGR AQSQEDGDYI NANYIRGYDG KEKVYIATQG PMPNTVSDFW
   181  EMVWQEEVSL IVMLTQLREG KEKCVHYWPT EEETYGPFQI RIQDMKECPE YTVRQLTIQY
   241  QEERRSVKHI LFSAWPDHQT PESAGPLLRL VAEVEESPET AAHPGPIVVH CSAGIGRTGC
   301  FIATRIGCQQ LKARGEVDIL GIVCQLRLDR GGMIQTAEQY QFLHHTLALY AGQLPEEPSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

71 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.09

gnomAD pLI

0

gnomAD missense Z

1.2

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• MAPK cascade
• protein dephosphorylation
• signal transduction

Molecular functions

• non-membrane spanning protein tyrosine phosphatase activity
• protein tyrosine phosphatase activity

Cellular components

• cytoplasm
• cytoplasmic side of plasma membrane
• cytosol
• microtubule cytoskeleton
• mitotic spindle
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Tyrosine-specific protein phosphatase, PTPase domain
• Tyrosine-specific protein phosphatases domain
• Protein-tyrosine phosphatase, catalytic
• Protein-tyrosine phosphatase, KIM-containing
• Protein-tyrosine phosphatase, active site
• Protein-tyrosine phosphatase-like
• Protein-tyrosine phosphatase

KeywordsUniProt

• Cytoplasm
• Cytoskeleton
• Hydrolase
• Oxidation
• Phosphoprotein
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of PTPN7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAPK1
• MAPK3